Sapitinib-fumarate-AZD-8931-fumarate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Sapitinibfumarate

Cat.No.:HY-13050A

CASNo.:1196531-39-1

Synonyms:AZD-8931fumarate

分⼦式:C₃₁H₃₃ClFN₅O₁₁

分⼦量:706.07

作⽤靶点:EGFR

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Sapitinibfumarate是可逆的，ATP竞争型EGFR抑制剂，对EGFR，ErbB2和ErbB3的IC50值分别为4，3和4

nM。

客户使⽤本产品发表的科研⽂献

•SciTranslMed.2018Jul18;10(450).pii:eaaq1093.

•CellRep.2023May29;42(6):112570.

•JTranslMed.2021Jan23;19(1):43.

•MolCancerRes.2019Jan;17(1):20-29.

•BioorgChem.2024Apr29:147:107412.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].HickinsonDM,etal.AZD8931,anequipotent,reversibleinhibitorofsignalingbyepidermalgrowthfactorreceptor,ERBB2(HER2),and

ERBB3:auniqueagentforsimultaneousERBBreceptorblockadeincancer.ClinCancerRes.2010Feb15;16(4):1159-69.

[2].MuZ,etal.AZD8931,anequipotent,reversibleinhibitorofsignalingbyepidermalgrowthfactorreceptor(EGFR),HER2,andHER3:

preclinicalactivityinHER2non-amplifiedinflammatorybreastcancermodels.JExpClinCancerRes.2014May30;33:47.

[3].BarlaamB,etal.DiscoveryofAZD8931,anEquipotent,ReversibleInhibitorofSignalingbyEGFR,HER2,andHER3Rec