GSK256073-tris-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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GSK256073tris

Cat.No.:HY-119222A

CASNo.:1228650-42-7

分⼦式:C₁₄H₂₄ClN₅O₅

分⼦量:377.82

作⽤靶点:GPR109A

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性GSK256073tris是⼀种有效的、选择性的、⼝服活性的GPR109A激动剂，是⼀种持久的HCA2激动剂，其

pEC50为7.5(HumanHCA2)。GSK256073tris可通过抑制脂降解⽽明显改善葡萄糖稳态，具有研究2型糖尿

病(T2DM)和⾎脂异常的潜⼒。

客户使⽤本产品发表的科研⽂献

•CancerCell.2024Oct14;42(10):1729-1746.e8.

•bioRxiv.2023Jul3.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].DobbinsRL,etal.GSK256073,aselectiveagonistofG-proteincoupledreceptor109A(GPR109A)reducesserumglucoseinsubjects

withtype2diabetesmellitus.DiabetesObesMetab.2013Nov;15(11):1013-21.

[2].SprecherD,etal.DiscoveryandcharacterizationofGSK256073,anon-flushinghydroxy-carboxylicacidreceptor2(HCA2)agonist.Eur

JPharmacol.2015Jun5;756:1-7.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.