Foretinib-phosphate-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Foretinibphosphate

Cat.No.:HY-10338A

CASNo.:1226999-07-0

分⼦式:C₃₄H₄₀F₂N₄O₁₄P₂

分⼦量:828.64

作⽤靶点:c-Met/HGFR;VEGFR

作⽤通路:ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Foretinibphosphate是⼀种具有潜在抗肿瘤活性的⼝服⽣物可利⽤⼩分⼦。Foretinibphosphate能够选择性

地抑制肝细胞⽣长因⼦（HGF）受体c-MET和⾎管内⽪⽣长因⼦受体2（VEGFR2），从⽽可能抑制肿瘤的⾎管

⽣成、肿瘤细胞增殖和转移。Foretinibphosphate在肺癌细胞中显⽰出与cabozantinib不同的抗癌活性，并且

对MEK1/2、FER和AURKB等靶点具有更强的抑制作⽤。

客户使⽤本产品发表的科研⽂献

•CancerDiscov.2021Jan;11(1):126-141.

•NatBiomedEng.2018Aug;2(8):578-588.

•SciTranslMed.2018Jul18;10(450).pii:eaaq1093.

•CellChemBiol.2018Feb15;25(2):206-214.e11.

•CellRepMethods.2023Oct23;3(10):100599.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].QianF,etal.Inhibitionoftumorcellgrowth,invasion,andmetastasisbyEXEL-2880(XL880,GSK1363089),anovelinhibitorofHGF

andVEGFreceptortyrosinekinases.CancerRes,2009,69(20),8009-8016.

[2].KataokaY,etal.Foretinib(GSK1363089),amulti-kinaseinhibitorofMETandVEGFRs,inhibitsgrowthofgastriccancercelllinesby

blockinginter-receptortyrosinekinasenetworks.InvestNewDrugs,2011.

[3].EderJP,etal.AphaseIstudyofforetinib,amulti-tar