GS-441524-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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GS-441524hydrochloride

Cat.No.:HY-103586A

CASNo.:2378280-82-9

分⼦式:C₁₂H₁₄ClN₅O₄

分⼦量:327.72

作⽤靶点:DNA/RNASynthesis;SARS-CoV

作⽤通路:CellCycle/DNADamage;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性GS-441524hydrochloride是Remdesivir的主要活性代谢物，活性更优于Remdesivir，感染病毒的原代⼈肺

和猫细胞的细胞模型中显⽰出相似的活性。GS-441524hydrochloride对猫传染性腹膜炎病毒(FIPV)有较强的

抑制作⽤，对应的EC50值为0.78μM。

客户使⽤本产品发表的科研⽂献

•NucleicAcidsRes.2021Jan8;49(D1):D1113-D1121.

•NatCommun.2021Nov5;12(1):6415.

•JMedVirol.2021Mar5.

•NanoLett.2023Oct25;23(20):9437-9444.

•BiomedPharmacother.2022Nov22;157:114037.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].MurphyBG,etal.ThenucleosideanalogGS-441524stronglyinhibitsfelineinfectiousperitonitis(FIP)virusintissuecultureand

experimentalcatinfectionstudies.VetMicrobiol.2018Jun;219:226-233.

[2].KatherineYang,etal.WhatDoWeKnowAboutRemdesivir