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SepsisandSepticShock
脓毒症及脓毒性休克;Definitions;Definitions;;Definitions;Definitions;Definitions;SIRSandSepsis;;;;Epidemiology;2002年目标：5年内死亡率降低25%;14;CritCareMed.2014Mar;42(3):625–631;“SevereSepsis”istheleadingcauseofdeathin(noncoronary)ICU
11thleadingcauseofdeathoverall
Morethan750,000casesofseveresepsisinUSannually.
IntheUS,morethan500patientsdieofseveresepsisdaily
InEuropeanICUs,sepsisandseveresepsisoccurin30%and37%ofthepatients
severesepsisasthethirdmostcommoncauseofdeathintheUnitedStatesafterheartdiseaseandmalignanttumors
;Epidemiology;sepsisisbecomingmorecommon,especiallyinthehospital,asaresultof:
Medicalandtechnologicaladvancesassociatedwithtreatments
Theincreasingnumberofelderlyordebilitatedpeople,andpatientswithunderlyingdiseasessuchascancer,whorequiretherapy
Thewidespreaduseofantibiotics,whichencouragesthegrowthofdrug-resistantmicroorganisms
;Martinetal:NEnglJMed2003:348:1546;USNationalCentreHealthStatistics–June2011;Martinetal:NEnglJMed2003:348:1546;Epidemiology;Mortality：
1.InferiorAMI5%
2.TraumaISS16-247%
3.GIH+lowBP11%
4.SepticShock25%
5.SevereDKA1%;;Forthoseunderage65,13%ofthosehospitalizedforsepticemiaorsepsisdiedinthehospital,comparedwith1%ofthosehospitalizedforotherconditions.
Forthoseaged65andover,20%ofsepticemiaorsepsishospitalizationsendedindeathcomparedwith3%forotherhospitalizations.
Only2%ofhospitalizationsin2008wereforsepticemiaorsepsis,yettheymadeup17%ofin-hospitaldeaths
;Patientshospitalizedforsepticemiaorsepsisweremorethaneighttimesaslikelytodieduringtheirhospitalization
;Only2% ofhospitalizations in2008wereforsepticemiaorsepsis,yettheymadeup17%ofin-hospital deaths;TotalnationwideinpatientannualcostsoftreatingthoseHo
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