贝那普利和阿法骨化醇联合治疗糖尿病肾病的疗效研究.docVIP

·3268 · · 论 著 · 贝那普利和阿法骨化醇联合治疗糖尿病肾病的疗效研究 徐鹏，陈星华 【摘要】 目的 观察贝那普利联合阿法骨化醇治疗糖尿病肾病的临床疗效。方法 120例符合入选条件的住院 及门诊的糖尿病肾病患者被随机分为3组，每组40例，分别进行单用贝那普利(10～20 mg/d), 单用阿法骨化醇 (0.5μg/d) 以及联合贝那普利(10～20 mg/d) 和阿法骨化醇(0.5μg/d) 治疗，血压均控制在125/75 mm Hg以下， 疗程为12周，治疗前后测定3组患者的血压、24 h 尿蛋白定量、血清肌酐、尿素氮、空腹血糖、血钾、血钙等水平， 同时观察治疗期间有无严重不良反应。 结果 120例患者治疗期间无严重不良反应(如高血压、低血压、高钾等)发 生。治疗前3组患者的血肌酐、尿素氮、空腹血糖、血钾、血钙、血压、24 h 尿蛋白定量间差异均无统计学意义 (P 0.05),经过12周治疗后3组患者24h 尿蛋白定量间差异有统计学意义 (P0.05), 且联合治疗组24h 尿蛋白定量 降低更明显，与贝那普利组及阿法骨化醇组比较，差异均有统计学意义 (P0.05)。 结论 贝那普利和阿法骨化醇均 能减轻糖尿病肾病患者的蛋白尿，发挥肾脏保护作用，但联合应用疗效更佳。 【关键词】 贝那普利；阿法骨化醇；糖尿病肾病；治疗结果 【中图分类号】 R587.24 【文献标识码】 A 【文章编号】1007-9572(2010)10-3268-03 Effect of Combined Therapy with Benazepril and Alfacalcidol in Patients with Diabetic Nephropathy XU Peng,CHEN Xing-hua. Department of Emergency, the First Hospital of Xiangfan,Xiangfan 441000,China 【Abstract] Objective To investigate the effect of combined therapy with Benazepril and Alfacalcidol in patients with diabetic nephropathy. Methods 120 diabetic nephropathy patients in our hospital were enrolled. All patients were randomly di- vided into three groups. Group A(26 males and 14 females)were treated by Alfacalcidol 0.5 μg per day,Group B(25 males and 15 females) were treated by Benazepril 10～20 mg per day,Group C(24 males and 16 females) were treated by Benazepril 10～20 mg and Alfacalcidol 0.5 μug per day. The blood pressure of all the patients was controlled below 125/75 mm Hg. The se- rum creatinine(SCr),urea nitrogen (BUN),fasting blood glucose(FBG),potassium(K*),calcium(Ca2*)and 24 h urinary protein were measured before the experiment and 12 weeks later. Results There were no obvious adverse effects during the treatments in all the groups. There were no significant differences in the serum creatinine,urea nitrogen, fasting blood sug- ar,potassium, calcium among the three groups before the experiment(P0.05). While 24 h urine protein were all signifi- cantly decreased(P0.05)in