降钙素基因相关肽与青壮年胆汁反流的关系探讨（职称论文资料）.docVIP

降钙素基因相关肽与青壮年胆汁反流的关系探讨（职称论文资料） 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：降钙素基因相关肽与青壮年胆汁反流的关系探讨 1 见表1。 4 3 讨论 4 文2：降钙素基因相关肽与糖尿病肾病的关系 5 1 对象与方法 5 2 结 果 7 3 讨 论 8 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 10 正文 降钙素基因相关肽与青壮年胆汁反流的关系探讨（职称论文资料） 文1：降钙素基因相关肽与青壮年胆汁反流的关系探讨 The Relatiohip of Calcitonin Gene-related Peptide and Bile Reflux in the Young and Middle-aged Patients ZHANG Lijin LIN Zhihui ZHENG Xiaoling FANG Chaoying Fujian Provincial Hospital，Fuzhou 350001，China [Abstract] Objective To study the relatiohip of calcitonin gene-related peptide and bile reflux in the the young and middle-aged patients. Methods Pyloric mucosal calcitonin gene-related peptide concentration of 45 young and middle-aged patients with bile reflux and 45 control group were detected. Endogastric bile acid of the young and middle-aged patients with bile reflux were detected simultaneously. Results The level of pyloric mucosal calcitonin gene-related peptide concentration was decreased evidently in young and middle-aged patients with bile reflux. Compared with control group，the difference has statistics significance（P＜）. There is no distinct correlatatiohip among calcitonin gene-related peptide and endogastric bile acid. Conclusion The decrease of gastric mucosal calcitonin gene-related peptide may be involved in the gastric mucosa adaptive protection of bile reflux in the young and middle-aged patients. [Key words] Bile reflux；Calcitonin gene-related peptide；Endogastric bile acid；Young and middle-aged people 随着胃镜检查的普及，临床上青壮年胆汁反流的检出率比较高，但原因不明。本研究旨在通过对45例青壮年原发性胆汁反流患者幽门区黏膜降钙素基因相关肽（CGRP）含量及胃液胆汁酸浓度的测定，探讨降钙素基因相关肽在青壮年胆汁反流发病中的作用。 1 资料与方法 一般资料 选择非术后、幽门完整且不伴有消化性溃疡、胃十二指肠肿瘤及胆道疾病的青壮年，内镜检查明确为胆汁反流Ⅲ度（黄色液体从幽门口频繁涌出或（和）持续性喷射出或胃内布满黄绿色潴留液）的患者共45例，全部来自我院消化内镜中心2009年8月～2011年6月的门诊患者，其中男19例，女26例，年龄19～45岁，平均岁（有5例患者胃镜检查前曾行24小时胃内胆汁监测确定存在碱反流）。同步选择45例内镜检查无明显异常的青壮年健康体检者为对照者，男21例，女24例，年龄20～45岁，平均岁。排除消化系统器质性病变，如消化道肿瘤，肝、胆、胰、肠道病变等，排除肝胆胃肠手术史。检查前2周未使用胃肠动力药、制酸剂及胃黏膜保护剂等所有影响胃动力和胃肠分泌功能的药。 方法 对符合上述各项标准的胆汁反流组45例及对照组45例均作电