冠心病全英文模式.pptxVIP

Coronary Heart Disease (Ischemic Heart Disease);Content:;CHD is defined as myocardial impairment due to an imbalance between coronary blood flow and myocardial requirements caused by changes in the coronary circulation;Manifestation of Ischemia Heart Disease;Acute coronary syndrome;美国*r血管病流彳亍病学;中国，4血管病流彳亍病学;Atherosclerosis;Objective;Risk factors ★ Irreversible risk factors 1- Age 2. Male sex 3. Family History;2)Relative large clinical trial ★4S,WOSCOPS,CARE,AFCAPS,LIPID enroll 30817 patients, follow up 4.5 years. 去TC decrease 20%,TG decrease 13% LDL-C decrease 28%,HDL increase 5% ★ Morbidity of major coronary events decrease 31%;Pathogenesis;4.endothelial injure hypothesis ★ Endothelial dysfunction;* Modification of LDL can lead to endothelial dysfunction M □ DI Fl CATION DF LDL CAN LEAD 丁口 E：N DOTH ELI AL DYSFUNCTION ： ROLE OF Diabetes and Hypertension;太 Role of macrophage Excrete growth factor platelet-derived growth factor Endothelial growth factor Transformatic growth factor B;Endothelial adhesion;Fatty streak;临床疾病;Clinical manifestation;Foam Fatty Intermediate Atheroma Complicated Fibrous cells streak lesion lesion/r upture plaque;l.no symptom phase l.ischemia phase 3. necrotic phase 4. fibrosis phase;Cerebral infarct;Investigation;Prevention and treatment;血脂 咼血压 戒烟 糖尿病 +初级预防;初级预防;?定义：又称为原发性预防，即消除 或减少致病危险 因素，减少个人发 病机会，降低群体的 发病率;?多项荟萃分析结果证明:;?定义：指对已患心血管病的病人;?二级预防能使CVD患者总死亡率下降 20% -30%,中风及需要血运重建的 机率降低20%, 患者的生活质量提高 ?多项研究证实： -二级预防能提高急性冠脉综合征 患者的生存率，降低其死亡率及病 残率;二级预防指南;Medicine