课件:CYC基因多态性与氯吡咯雷反应变异性的研究进展.ppt

课件:CYC基因多态性与氯吡咯雷反应变异性的研究进展.ppt

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Chris Terpening. Clopidogrel: A pharmacogenomic perspective on its use in coronary artery disease. Clinical Medicine Insights: Cardiology 2010:4 117-128 Renée M. Ned, Genetic Testing for CYP450 Polymorphisms to Predict Response to Clopidogrel: current evidence and test availability Application: Pharmacogenomics。PLoS Curr. 2010 September 20; 2: RRN1180. doi: 10.1371/currents.RRN1180. Pettersen et al. The influence of CYP2C19*2polymorphism on platelet function testing during single antiplatelet treatmeng with clopidogrel . Thrombosis journal 2011,9:4 Pettersen et al. The influence of CYP2C19*2polymorphism on platelet function testing during single antiplatelet treatmeng with clopidogrel . Thrombosis journal 2011,9:4 Pettersen et al. The influence of CYP2C19*2polymorphism on platelet function testing during single antiplatelet treatmeng with clopidogrel . Thrombosis journal 2011,9:4 Trenk.D, Hochholzer.W, Fromm. M. et al Cytochrome P450 2C19 681GA polymorphism and high On-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting of bare-metal stents.J Am Coll Cardiol 2008;51:1925-1934 Shuldiner.AR,Connel.JFO. Bliden.kp. Et al. Association of cytochrome P4502C19 Genotype with the antiplatelet effect and Clinical efficacy of clopidogrel therapy .JAMA, 2009;302(8):849-858 Jessical, Mega, Sandral.Close et al. Cytochrome P450 polymorphism and response to Clopidogrel. New Engl J Med 2009;360:354-362 Mega.JL, Simon.t, Collet.JP, et al. Reduces-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI A Meta-analysis.JAMA. 2010;304:1821-1830 Renée M. Ned, Genetic Testing for CYP450 Polymorphisms to Predict Response to Clopidogrel: current evidence and test availability Application: Pharmacogenomics。PLoS Curr. 2010 September 20; 2: RRN1180. Simon.T, Verstuytf.C, Mary-Krause.M, et al.Genetic determinants of response

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