Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography–tandem mass spectrometry 超滤-液相色谱-串联质谱法分析复方靛蓝.pdfVIP

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Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography–tandem mass spectrometry 超滤-液相色谱-串联质谱法分析复方靛蓝.pdf

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Journal of Pharmaceutical and Biomedical Analysis 59 (2012) 96–101 Contents lists available at SciVerse ScienceDirect Journal of Pharmaceutical and Biomedical Analysis j o u r na l h o me p a g e : w w w. elsev /locate/jpba Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultraﬁltration and liquid chromatography–tandem mass spectrometry Shu Liu a,c , Jun Yan b , Junpeng Xing a , Fengrui Song a , Zhiqiang Liu a,∗ , Shuying Liu a a Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China b College of Pharmacy, Jilin University, Changchun 130021, PR China c Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China a r t i c l e i n f o a b s t r a c t Article history: The liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods were used to identify the Received 4 July 2011 pharmacologically active n-butanol extract from Compound Indigowoad Root Granule. As a result, eighteen Received in revised form 14 October 2011 compounds belonging to various structural classes such as nucleosides, purines, ﬂavonoids and amino Accepted 15 October 2011 acid were unambiguously identiﬁed. Then an in vitro neuraminidase (NA) inhibition assay was carried out Available online 20 October 2011 to examine the inhibitory activity of the standard samples and extracts on NA. After which, ultraﬁltration liquid chromatography with photodiode array d