结核抗体检测在儿童结核病中的诊断价值.docVIP

结核抗体检测在儿童结核病中的诊断价值 　　[摘要] 目的 研究结核抗体检测在儿童结核病中的诊断价值。方法 随机选取该院2013年4月―2014年5月收治的60例儿童结核病患儿作为观察组，选取该院同期非结核病患儿60例作为对照组。对两组患儿采用结核菌素试验（PPD试验）和血清结核抗体检测并对两组结果比较分析。结果 观察组PPD试验阳性例数47例、阳性率78.3%相较结核抗体检测阳性例数21例、阳性率35.0%显著较高（P0.05），结核抗体检测灵敏度较低；对照组PPD试验阳性例数12例、阳性率20%相较对照组结核抗体检测阳性例数0例、阳性率0显著较高，差异有统计学意义（P0.05），结核抗体检测特异性较高。结论 结核抗体检测适合作为一种儿童结核病诊断参考，联合其他诊断方法兼顾灵敏度和特异性，具有重大医疗价值。 　　[关键词] 结核病；结核抗体检测；诊断价值 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）11（c）-0177-02 　　[Abstract] Objective To study the diagnostic value of tuberculosis antibody detection in children with tuberculosis. Methods 60 cases of children with tuberculosis were selected as the observation group and 60 cases of non -tuberculosis patients were selected as the control group， both groups were treated in the hospital from April 2013 to May 2014. The tuberculin test（PPD test） and serum tuberculosis antibody detection were performed in the two groups of children， and the results of the two groups were comparatively analyzed. Results There were 47 positive cases detected by PPD test and the positive rate was 78.3% which were significantly higher than 21 cases and 35.0% of tuberculosis antibody detection， and the differences were statistically significant（P0.05）. The sensitivity of tuberculosis antibody detection was lower. The positive cases and rate by PPD test of the observation group were 12 cases and 20%， which were significantly higher than 0 case and 0 of the control group， and the differences were statistically significant（P0.05）， the specificity of tuberculosis antibody detection is higher. Conclusion The tuberculosis antibody detection is suitable for being taken as a reference for diagnosis of children with tuberculosis， which is of sensitivity and specificity combined with other diagnostic methods and is of important medical value. 　　[Key words] Tuberculosis； Tuberculosis antibody detection； Diagnostic value 　　结核病（TB）是一种严重可致命的多发疾病，该病主要是由分支杆菌又称结核杆菌导致。患者一般有全身不适乏力、体温发热、盗汗、吼喘咳痰、胸痛烦闷等症状表现[1]。结核病对肺、淋巴系统、脑中枢神经系统、骨骼组织甚至