稳心颗粒与比索洛尔治疗心率增快型功能性室性早搏对比研究.docVIP

稳心颗粒与比索洛尔治疗心率增快型功能性室性早搏对比研究 　　[摘要] 目的：对比稳心颗粒与比索洛尔对心率增快型功能性室性早搏的疗效。方法：采用动态心电图随机将24 h总心率大于11万次心搏的功能性室性早搏分为稳心颗粒组、比索洛尔组、联合用药组，每组均为40例。稳心颗粒组口服稳心颗粒1包（9 g）/次，3次/d；比索洛尔组口服比索洛尔5 mg/次，1次/d；联合用药组按上述剂量两药合用，三组均以4周为1个疗程，观察用药前后总心率、临床症状、室性早搏次数及不良反应情况。结果：稳心颗粒组、比索洛尔组、联合用药组的有效率分别为77.5%、72.5%、92.5%；临床症状改善率稳心颗粒组、比索洛尔组、联合用药组分别为82.5%、57.5%、90.0%。结论：稳心颗粒治疗心率增快型功能性室性早搏疗效与比索洛尔相似，但临床症状改善率明显优于比索洛尔组（P＜0.05），若两药合用，降低总心率、治疗室性早搏及改善临床症状均优于单一用药。 　　[关键词] 稳心颗粒；比索洛尔；室性早搏 　　[中图分类号] R541.7+1[文献标识码]B [文章编号]1673-7210（2008）02（b）-070-02 　　 　　The comparative study of effects of Wenxin Granules and Bisoprolol on treating patients with increasing heart rate and functional ventricular premature beat 　　ZHANG Ying1,ZHANG Yong-qing2,CHEN Chuan-qin2,DU Su-hua2，LIU Ru-pin2,FU Xing2 　　(1.Xinyang Military Sub-area Health Place of Henan Province, Xinyang 464000,China;2.Xinyang Central Hospita of Henan Province，Xinyang 464000, China) 　　[Abstract] Objective:To compare the curative effect of Wenxin Granule and Bisoprolol in the treatment of increasing heart rate and functional ventricular premature beat.Methods:The patients with functional ventricular premature beat,which total heart rate exceeding 11 ten thousand times over past 24hours monitored by dynamic cardiotachograph,was randomly signed into three groups:group 1(treated with Wenxin Granule,9 g,tid,po),group 2(treated with Bisoprolol,5 mg,qd,po)and group 3(treated with Wenxin Granule and Bisoprolol,the dosage as the same as above mentioned),the course of treatment was four weeks in three groups,for observing the clinical symptom,premature beat frequency and heart rate in before and after the treatment.Results:The clinical symptom improving rate and the curative effect were 82.5%and 77.5%, 57.5% and72.5%, 90.0%and92.5%, in group 1,2 and 3,respectively. Conclusion:The curative effect of Wenxin Granule on treating increasing heart rate and functional ventricular premature beat as the same as that of Bisoprolol(P＜0.05),and group 3 is superior to group 2 and 1,n