药物缓释材料丙烯酸酯改性水性聚氨酯的分析及应用-analysis and application of acrylate modified waterborne polyurethane as drug slow-release material.docxVIP

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药物缓释材料丙烯酸酯改性水性聚氨酯的分析及应用-analysis and application of acrylate modified waterborne polyurethane as drug slow-release material.docx

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药物缓释材料丙烯酸酯改性水性聚氨酯的分析及应用-analysis and application of acrylate modified waterborne polyurethane as drug slow-release material

The Research and Application about Acrylic-Modified Waterborne Polyurethane on Drug Slow-Release Materials AbstractDrug slow-release material is a class of polymer materials，which can delay the drug torelease for more than eight hours. It’s very important for the field of medicament, it is also the one of the important research direction for chemistry, biology, material science. The use of fine drug slow-release materials can reduce or avoid clinical adverse drug reactions due to high concentration. All of these can reduce times of taking medicine, improve patient compliance degrees, and guarantee continuity of the medical treatment, at same time it can improve the accuracy and validity of drug treatment.In the research, isophorone diisocyanate(IPDI) and polytetrahydrofuran glycol (PTMG) were used as the basic raw material, dimethylolpropionic acid (DMPA) is as extension agent and 2-hydroxyethyl methacrylate (HEMA) is as coupling agent. Acrylic-modifiedwaterborne polyurethane( 1, 4-butyl glycol (BDO) is also as chain extension) has been synthesized by a chemical process of nuclear shell emulsion copolymerization. The acrylic ester has been successfully introduced to molecular of waterborne polyurethane by detecting of the infrared spectrum . The influencing relation between the content of DMPA, R value, MMA , the weight of solid and the factors of WPUA appearance, viscosity, stability, peel strength, ratio of absorbing water , tensile strength had been studied . The results show: when the content of DMPA is 6%, ratio of PU/PA is 8:2 and the content of solid is 35%-40%, the performance index of WPUA emulsion and film of glue is excellent .On the condition of optimum synthetic technology, hydroxypropyl silicone oil (PDMS) was put in. The influence about the weight of organic silicone compound had been treated. Experiments indicate that the organic silicon has been already inset to molecular chain, the optimum content of organic silicon is 10% to13%.The study also util