妊娠期糖尿病的性激素结合蛋白-sex hormone binding protein in gestational diabetes mellitus.docxVIP

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妊娠期糖尿病的性激素结合蛋白-sex hormone binding protein in gestational diabetes mellitus.docx

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妊娠期糖尿病的性激素结合蛋白-sex hormone binding protein in gestational diabetes mellitus

ContentsABBREVIATIONS ....................................................................................................................IIABSTRACT.............................................................................................................................. IIIChinese Abstract ....................................................................................................................... IVINTRODUCTION 1SEX HORMONE 1Introduction and structure 1Biosynthesis 1Regulation 1SEX HORMONE BINDING GLOBULIN 1Structure 1Functions 2Regulation 2DIABETES MELLITUS 3Definition and classification 3Pathophysiology 3Diagnosis 4GESTATIONAL DIABETES MELLITUS 4Definition 4Pathophysiology 4Diagnosis 4METHODS AND MATERIALS 5STATISTICAL ANALYSES 6ETHICAL ISSUES 6RESULTS 7DISCUSSION 10CONCLUSION 12CONFLICT OF INTEREST 13ACKNOWLEDGEMENTS 13REFERENCES 14ABBREVIATIONSADA – American Diabetes AssociationBMI – Body Mass indexCRP – C Reactive ProteinDBP – Diastolic Blood Pressure DHT – Dihydro Testosterone DM – Diabetes MellitusFPG – Fasting Plasma GlucoseGDM – Gestational Diabetes MellitusGH – Growth HormoneHAPO – Hyperglycemia and Adverse Pregnancy OutcomesHIV – Human Immunodeficiency VirusHOMA – Homeostasis Model AssessmentIADPSG – International Association of Diabetes and Pregnancy Study GroupsIGF – Insulin like Growth Factor mRNA – messenger Ribo Nucleic Acid OGTT – Oral Glucose Tolerance Test PCOS – Poly Cystic Ovarian Syndrome RPG – Random Plasma GlucoseSBP – Systolic Blood PressureSHBG – Sex Hormone Binding Globulin T1DM– Type 1 Diabetes Mellitus T2DM – Type 2 Diabetes Mellitus WHO – World Health OrganizationABSTRACTAims: The aim of this study was to measure and compare maternal plasma SHBG concentrations in normal pregnancy and in GDM patients, and thereafter determine the association between SHBG and GDM.Materials and Methods: This was a prospective, case-control study with a total of 60 participants in their third trimester of pregnancy. The control group had 28 w