ii hladr蛋白在潮汕食管癌组织中表达及意义-expression and significance of ii h ladr protein in chaoshan esophageal carcinoma tissue.docx

下载文档 降价啦

0
0
约6.13万字
约 57页
2018-05-29 发布于上海
举报
版权申诉
保障服务

ii hladr蛋白在潮汕食管癌组织中表达及意义-expression and significance of ii h ladr protein in chaoshan esophageal carcinoma tissue.docx

1、本文档共57页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

ii hladr蛋白在潮汕食管癌组织中表达及意义-expression and significance of ii h ladr protein in chaoshan esophageal carcinoma tissue

HLA-DR. For each section, immunohistochemically positive tumor cells were counted in 5 points under high power fields(×400) and the percentage of positive cells was calculated by Image-Pro Plus 6.0 analytical system.SIMPLE stain: The formalin-fixed, paraffin-embedded sections were stained usingSIMPLE technology , Ii and HLA-DR antigens were detected. Each section was used automatic biological microscope to collect photos in the same position.ResultsNormal esophagus and low grade intraepithelial neoplasia was negative for Ii while expressed in high grade intraepithelial neoplasia and oesophageal squamous cell carcinoma. Normal, low grade intraepithelial neoplasia and high grade intraepithelial neoplasia compared tothe esophageal squamous cell carcinoma respectively, Ii incresed in the latter（P＜0.01）. Therewas significance of difference in expression of Ii between normal and high grade intraepithelial neoplasia（P＜0.05）While not between the low grade intraepithelial neoplasia and high grade intraepithelial neoplasia（P＞0.05）.The positive expression rate of Ii is increase in the progression from low-to-high grade tumors（P＜0.05）.The expression of HLA-DR protein was negative in normal esophagus samples and little in low grade intraepithelial neoplasia,while increased in high grade intraepithelial neoplasia and esophageal squamous cell carcinoma. There was no significance between normal esophagusand low grade intraepithelial neoplasia（P＞0.05） , so did high grade intraepithelial neoplasiaand esophageal carcinoma（P＞0.05）. However,there was significance in expression of HLA-DR that normal group compared to high grade intraepithelial neoplasia and esophagealsquamous cell carcinoma respectively(P＜0.01）, so did low grade intraepithelial neoplasia (P＜0.01）.The co-expression of Ii and HLA-DR are detected in esophgeal squamous cell carcinoma and Ii expression is positively correlated with HLA-DR expression（P＜0.05，rs=0.358）. The result is confirmed by SIMPLE method.The quanti