from inflammaging to healthy aging by dietary lifestyle choices is epigenetics the key to personalized nutrition：从inflammaging通过选择饮食生活方式健康老龄化是表观遗传学个性化营养的关键精品.pdfVIP

vel Szic et al. Clinical Epigenetics (2015) 7:33 DOI 10.1186/s13148-015-0068-2 REVIEW Open Access From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? 1 1 2 1* Katarzyna Szarc vel Szic , Ken Declerck , Melita Vidaković and Wim Vanden Berghe Abstract The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. The heterogeneity in biological aging, chronological age, and aging-associated disorders in humans have been ascribed to different genetic and environmental factors (i.e., diet, pollution, stress) that are closely linked to socioeconomic factors. The common denominator of these factors is the inflammatory response. Chronic low-grade systemic inflammation during physiological aging and immunosenescence are intertwined in the pathogenesis of premature aging also defined as ‘inflammaging.’ The latter has been associated with frailty, morbidity, and mortality in elderly subjects. However, it is unknown to what extent inflammaging or longevity is controlled by epigenetic events in early life. Today, human diet is believed to have a major influence on both the development and prevention of age-related diseases. Most plant-derived dietary phytochemicals and macro- and micronutrients modulate oxidative stress and inflammatory signaling and regulate metabolic pathways and bioenergetics that can be translated into stable epigenetic patterns of gene expression. Therefore, diet interventions designed for healthy aging have