new antimicrobial peptides against foodborne pathogens_ from in silico design to experimental evidence.pdf.新的抗菌肽对食源性pathogens_从硅片实验eviden.pdfVIP

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new antimicrobial peptides against foodborne pathogens_ from in silico design to experimental evidence.pdf.新的抗菌肽对食源性pathogens_从硅片实验eviden.pdf

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new antimicrobial peptides against foodborne pathogens_ from in silico design to experimental evidence.pdf.新的抗菌肽对食源性pathogens_从硅片实验eviden

Food Chemistry 211 (2016) 546–554 Contents lists available at ScienceDirect Food Chemistry journal homepage: www.elsevi /locat e/foodchem New antimicrobial peptides against foodborne pathogens: From in silico design to experimental evidence Gianna Palmieri a,⇑,1, Marco Balestrieri a,1, Yolande T.R. Proroga b, Lucia Falcigno c, Angelo Facchiano d, Alessia Riccio a, Federico Capuano b, Raffaele Marrone e, Gianluca Neglia e, Aniello Anastasio e a Institute of Biosciences and BioResources (IBBR)-UOS Na, National Research Council (CNR-IBBR), Via Pietro Castellino 111, 80131 Naples, Italy b Department of Food Microbiology, Istituto Zooproﬁlattico Sperimentale del Mezzogiorno, via della salute, 2, 80055 Portici, Italy c Department of Pharmacy, University of Naples Federico II, Via Mezzocannone, 16, 80134 Naples, Italy d Institute of Food Science, National Research Council (CNR-ISA), Via Roma 52, 83100 Avellino, Italy e Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Federico Delpino 1, 80137 Naples, Italy a r t i c l e i n f o a b s t r a c t Article history: Recently there has been growing interest in the discovery of new antimicrobial agents to increase safety Received 8 January 2016 and shelf-life of food products. Here, we developed an innovative approach by introducing the concept Received in revised form 19 April 2016 that mitochondrial targeting peptides (MTP) can interact and disrupt bacterial membranes, acting as Accepted 16 May 2016 antimicrobial agents. As proof-of-pr