The ABO blood group and carcinoma of the stomach精选.pdfVIP

Department of Public Health, Yale University COLIN WHITE School of Medicine, and the Division of Cancer HENRY EISENBERG* * and Other Chronic Diseases, Connecticut State Department of Health ABO BLOOD GROUPS AND CANCER OF THE STOMACH In 1953 Aird et al. reported data which showed that the incidence of carcinoma of the stomach is higher in those subjects who belong to blood group A than in those of blood group 0. This paper provided a stimulus for several investigations, and by 1959 Lavenhar in a review was able to list results from 12 different centers. These showed that the mean incidence of cancer of the stomach was 21 per cent higher in group A than in group 0; the data therefore provide general confirmation of the findings of Aird et al. In one center with 1,146 cases, however, no difference between the two inci- dence rates was found, and in two other centers the difference was small and insignificant. In these circumstances it is worthwhile to investigate a sug- gestion first made by Jennings et al. that the relationship between blood group and carcinoma of the stomach might vary according to the site of the lesion within the stomach. The present interim report is based on the first half of the data we are collecting in order to test this hypothesis. MATERIALS AND METHODS The analysis covers 707 cases of gastric carcinoma registered at the Division of Cancer and Other Chronic Diseases, Connecticut State Department of Health, during the period 1950 to 1953. An additional 439 cases registered during this period were omitted from the final analysis because information about blood group or site of lesion was not available. Hospital records on each patient were consulted to obtain data on the site of the lesion. In 37 per cent of the cases the site was obtained from the pathologists r