重复经颅磁刺激治疗儿童多发性抽动症疗效观察.docVIP

精品论文 参考文献 重复经颅磁刺激治疗儿童多发性抽动症疗效观察 陈洁 　　（甘孜州人民医院内四科 626000） 　　【摘要】目的 观察重复经颅磁刺激（rTMS）对多发性抽动症（TS）患儿的疗效。方法 将41例TS患儿随机分为假刺激组（n=20）和治疗组(n=21)。2组患儿均接受1HZ、110%静息运动阈值、5次/周、1200脉冲/次、共计4周的rTMS治疗，假刺激组患儿接受假刺激线圈给予的rTMS治疗。于治疗前、治疗2周末及8周末，采用耶鲁综合抽动严重程度量表（YGTSS）评估TS患儿疗效。结果 与治疗前比较，治疗组患儿经rTMS治疗2周、8周后，其YGTSS评分较治疗前显著降低，差异具有统计学意义（plt;0.05）；与治疗前比较，假刺激组患儿治疗2周、8周后YGTSS评分与治疗前比较，差异无统计学意义（plt;0.05）。结论 rTMS可明显改善TS患儿的临床症状，值得临床推广应用。 　　【关键词】 重复经颅磁刺激 多发性抽动症 辅助运动区 儿童 　　【中图分类号】R720.5 【文献标识码】A 【文章编号】2095-1752（2014）02-0122-02 　　 　　Effects of low frequency repetitive transcranial magnetic stimulation for Tourettersquo;s syndrome. 　　Chen Jie 　　The fourth General Medicine, Ganzi peoplersquo;s hospital, 626000, Sichuan Province, China. 　　【Abstract】 Objective To investigate the effects of low frequency repetitive transcranial magnetic stimulation for children with Tourettersquo;s syndrome（TS）.Methods Thirty-one subjects with TS were randomly assigned to either the treatment group(n=21) or the sham rTMS treatment group(n=20). The rTMS treatment(1HZ、110% rest motor threshold、5 sections/week、1200 pluses/section、4 weeks) was given to treatment group subjects. For the sham group, the subjects received the same management process as those in the treatment group, but with a sham coil. The Yale global tic severity scale(YGTSS) was used to evaluate clinical performance of subjects at before treatment, 2 and 8 weeks post-treatment, respectively. Results Compared with the YGTSS score at baseline level, the sham rTMS group showed no significant improvement at 2 and 8weeks after treatment (pgt;0.05); Compared with the YGTSS score at baseline level, the rTMS group showed significant improvement at 2 and 8 weeks after treatment（plt;0.05）. Conclusion The low frequency rTMS has the potential to improve the clinical condition in children with TS. 　　多发性抽动症（Tourettersquo;s syndrome，TS）是一种以慢性多发运动性抽动和（或）发声抽动为主要特征的神经精神性疾病，在儿童中的发病率约0.05%[1]。TS症状常持续数年，不仅严重影响患儿生活质量，妨害其身心健