胎盘多肽注射液在轻中度职业性哮喘治疗中的疗效观察.docVIP

精品论文 参考文献 胎盘多肽注射液在轻中度职业性哮喘治疗中的疗效观察 黑龙江省二院 哈尔滨 150001 【摘 要】目的 观察胎盘多肽注射液对轻中度职业性哮喘急性发作的临床疗效。方法 将131例轻中度职业性哮喘分为治疗组和对照组。两组均按照职业性哮喘急性发作治疗流程进行治疗[1]，治疗组同时给予胎盘多肽注射液。两组分别在治疗前和治疗后1个月评估临床症状体征总评分和峰流速占预计值（PEF/Pred）百分比的变化。结果 两组在治疗后临床症状体征总评分及峰流速占预计值百分比与治疗前比较均有改善（Plt;0.05），且治疗后两组比较治疗组疗效明显优于对照组（Plt;0.05）。结论 轻中度职业性哮喘急性发作时，按照职业性哮喘急性发作治疗流程进行治疗的基础上，给予胎盘多肽注射液可显著提高疗效。 【关键词】胎盘多肽注射液；职业性哮喘；疗效 [Abstract]Objective To observe the clinical efficacy of placenta polypeptide injection in treatment of acute attack of mild and moderate occupational asthma.Methods 131 mild and moderate occupational asthma cases of acute attack were devided into the treated group and the control group.The two groups were treated according to the treatment processes of acute attack of occupational asthma，and the treated group was added to placenta polypeptide injection.Two groups were evaluated in the total score of clinical symptoms and signs and the percentage of peak expiratory flow to predicted value（PEF/Pred）before treatment and in a month after treatment.Results After treatment，two groups were improved in the clinical symptoms and signs and the percentage of PEF/Pred（plt;0.05），and efficacy of the treated group was improved significantly than the control group（plt;0.05）.Conclusion Which was treated according to the treatment processes of occupational asthma when acute attack of mild and moderate occupational asthma，and adding to placenta polypeptide injection can improve significantly clinical efficacy. [Key words]placenta polypeptide injection；occupational asthma；clinical efficacy 目前职业性哮喘急性发作主要使用糖皮质激素、支气管舒张剂、白三烯受体调节剂进行治疗。因细胞免疫在职业性哮喘发作过程中起着重要作用，近1年我们尝试使用胎盘多肽注射液进一步缓解职业性哮喘急性发作。现报道如下。 1 资料与方法 1.1一般资料 选择2015年1月至12月在我院住院的轻中度职业性哮喘患者131例，其中男性41人，女性90人，均符合轻中度职业性哮喘急性发作的诊断标准[1]。排除标准：（1）不能配合峰流速监测者。（2）合并意识障碍、心力衰竭、需要呼吸机辅助治疗者。本研究经我院伦理委员会审核通过，所有入组病人均签署知情同意书。两组患者入组前基本资料均无统计学意义（Pgt;0.05），见表1。 1.2方法 将入选患者分为两组，两组均按照职业性哮喘急性发作治疗流程进行治疗，治疗组同时给予胎盘多肽注射液4ml一日一次肌内注射，10日为一疗程，共用两个疗程。