气管、支气管唾液腺型癌外科治疗.docVIP

精品论文 参考文献 气管、支气管唾液腺型癌外科治疗 龙谦 梅宏 许川 张庆斌 孙永攀 刘波 刘迪 韩连奎 胡剑 罗猛（通讯作者） 　　[摘 要]背景与目的：原发性气管、支气管唾液腺型癌是一类低度恶性肿瘤，包括粘液表皮样癌、腺样囊性癌、上皮-肌皮样癌。临床报道相对较少，本文回顾分析单中心外科治疗该类肿瘤临床病理特征及预后。方法：收集2002年12月至2013年6月于贵州省人民医院胸外科接受外科手术治疗的42例唾液腺型癌患者资料，并随访，分析其临床病理特点及预后影响因素。结果：本组中粘液表皮样癌28例，腺样囊性癌14例，无上皮-肌皮样癌。腺样囊性癌位于气管或主支气管者更多（P＜0.05）。全组随访11-139月，平均57.2月。全组5年无复发生存率及总体生存率分别为62.6%和76.6%。单因素分析显示，伴淋巴结转移者（无论是N1阳性还是N2阳性）更易复发且总体生存率更差（P＜0.05）；多因素分析结果显示，伴有纵隔淋巴结转移是患者不良预后的独立影响因素。结论：对于气管、支气管唾液腺型癌，手术切除是首选治疗措施，能取得良好疗效。纵隔淋巴结转移是该类肿瘤不良预后的独立影响因素。 　　[关键词]唾液腺型癌 气管 支气管 外科手术 治疗 　　DOI:10.3760/cma.j.issn.0376-2491.2015.28.21 　　作者单位：550002，贵州省贵阳市，贵州市人民医院胸外科 　　Surgical Treatment of Tracheal and Bronchial Salivary Gland-type Carcinoma 　　Long Qian, Mei Hong, Xu Chuan, Zhang Qingbin, Sun Yongpan, Liu Bo, Liu Di, Han Liankui, Hu Jian, Luo Meng 　　Abstract: Objective Primary salivary gland-type carcinomas of trachea and bronchi are rare tumors that include mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and epithelial-myoepithelial carcinoma (EMC). They are low malignant neoplasms with distinct clinicopathological features and prognosis. Reports on them were little. Therefore, this paper aims to retrospectively analyze the clinicopathologic profiles of this carcinoma and patients long-term prognosis after surgical resection. Methods Clinical data of 42 patients with salivary-type carcinomas in the Department of Thoracic Surgery, Guizhou Provincial Peoplersquo;s Hospital from December 2002 to June 2013 were retrospectively selected and analyzed. Follow-up was conducted to each patient. The clinicopathologic profiles and factors influencing the long-term prognosis were analyzed. Results There were 28 cases of MEC and 14 cases of ACC while no EMC was presented. Compared with MEC, more ACC were located at trachea or main stem bronchi (P＜0.05). The mean period of follow-up was 57.2 months, range from 11 to 139 months. The 5-year recurrence-free survival (RFS) and overall survival (OS) were 62.6% and 76.6%, respec