不同剂量沙美特罗替卡松辅助治疗支气管哮喘临床评价.docVIP

不同剂量沙美特罗替卡松辅助治疗支气管哮喘临床评价 吕媛媛 刘洋 杨军 首都医科大学宣武医院 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 观察不同剂量沙美特罗替卡松辅助治疗支气管哮喘的临床疗效及安全性。方法 选择同期住院治疗的支气管哮喘患者92例, 随机均分为低剂量组与高剂量组, 两组在相同基础治疗基础上, 低剂量组给予沙美特罗替卡松吸入剂50μg/250μg, 高剂量组给予50μg/500μg。结果 高剂量组患者各临床症状缓解时间均短于低剂量组患者 (P0.05) ;治疗10 d后高剂量组患者肺功能指标与哮喘症状评分均优于低剂量组患者 (P0.05) , 治疗30 d与90 d后, 两组患者肺功能指标与哮喘症状评分差异无统计学意义 (P0.05) ;两组患者治疗期间均无严重不良反应。结论 支气管哮喘发作期应首选沙美特罗替卡松高剂量治疗, 利于患者临床症状的控制;稳定期应首选低剂量治疗, 哮喘症状控制满意且安全可靠。 关键词： 沙美特罗替卡松; 剂量; 支气管哮喘; 临床疗效; 安全性; 作者简介：吕媛媛 (1983-) , 女, 大学本科, 药师, 主要从事医院药剂科工作, (电话) 010 收稿日期：2017-04-10 Clinical Evaluation of Different Doses of Salmeterol and Fluticasone in Adjuvant Treatment of Bronchial Asthma Lü Yuanyuan Liu Yang Yang Jun Xuanwu Hospital Capital Medical University; Abstract： Objective To observe the clinical efficacy and safety of different doses of salmeterol and fluticasone in adjuvant treatment of bronchial asthma. Methods Totally 92 patients with bronchial asthma admitted to our hospital in the same period were selected and randomly divided into the low dose group and the high dose group. On the basis of same basic treatment, the low dose group and the high dose group were treated with 50 μg/250 μg, 50 μg/500 μg Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation, respectively. Results The remission time of the clinical symptoms in the high dose group was shorter than that in the low dose group ( P 0. 05) . After 10 d of treatment, the lung function index and asthma symptom score of the high dose group were better than those of the low dose group ( P 0. 05) . After 30, 90 d of treatment, there was no significant difference in lung function index and asthma symptom score between the two groups ( P 0. 05) . No serious adverse reactions occurred in the two groups during the treatment.Conclusion In the attack stage of bronchial asthma, high dose of salmeterol and fluticasone should be the first choice for treatment, which can control