d二聚体和肿瘤标志物与结直肠癌的相关性分析.docVIP

精品论文 参考文献 D二聚体和肿瘤标志物与结直肠癌的相关性分析 赣州市人民医院 江西 赣州 341000 作者简介：唐金凤，女，1979年，本科学历，研究方向：临床检验方面 通讯作者： 肖久长，男，1970年，本科学历，副主任技师，从事医学检验工作 [摘要]目的：探究D二聚体和肿瘤标志物与结直肠癌的相关性。方法：随机从本院2015年1月至2016年4月间收治入院的结直肠癌患者30例作为本次研究的观察组，并选取同期在院体检的健康者30例作为对照组，分别检测两组研究对象静脉血中的D-二聚体和血清肿瘤标记物（主要检测CEA、CA199、CA724水平）并予以观察组患者治疗，然后比较治疗前后上述指标变化情况，综合分析D二聚体和肿瘤标志物与结直肠癌的相关性。结果：观察组血清CEA、CA199、CA724以及D-二聚体水平显著高于对照组，且比较差异具有显著性（P＜0.05），并且观察组患者经过治疗后，CEA、CA199、CA724以及D-二聚体水平明显下降，且较治疗前差异显著（P＜0.05），且血清CEA、CA199、CA724以及D-二聚体高水平表达是影响结直肠癌临床预后的相关性因素。结论：血浆D二聚体和肿瘤标志物表达与结直肠癌发生情况有一定相关性，可以作为本病临床诊断及预后判断的指标。 关键词：结直肠癌；D-二聚体；肿瘤标志物；相关性分析 【中图分类号】R446.1【文献标识码】A【文章编号】1001-5213(2016)08-0287-02 [abstract] objective: to explore the D dimer and the correlation between tumor markers and colorectal cancer. Methods: random from our hospital between January 2015 and April 2016colorectal cancer patients admitted between 30 cases as the study group, and the same period in hospital medical examinations 30 cases of healthy subjects as control group, both groups was detected in the D - dimer in venous blood and serum tumor markers (mainly detect CEA, CA199, CA724 levels) and observation group of patients, and then compare the index changes before and after the treatment, comprehensive analysis of D dimer and the correlation between tumor markers and colorectal cancer. Results: the observation group of serum CEA, CA199, CA724 and D - dimer level is significantly higher than the control group, and compared with significant difference (P lt; 0.05), and the observation group of patients after treatment, CEA, CA199, CA724 and D - dimer level declined obviously, and the significant difference before treatment (P lt; 0.05), and serum CEA, CA199, CA724 and D - dimer express high levels of correlation factors of clinical prognosis of colorectal cancer. Conclusion: the serum D dimer and tumor markers in what is happening with colorectal cancer have certain relevance, can be used as index of clinical diagnosis and prognosis judgement. Key words: colorectal