大豆异黄酮对大鼠前列腺增生的抑制作用-中南大学学报医学版.pdfVIP

BU LL HUNAN MED UNIV 2003, 28(4) 343 任国峰, 黄忆明 ( 中南大学公共卫生学院营养与食品卫生学系, 长沙410078) [] 目的:探讨补充不同剂量大豆异黄酮对大鼠前列腺增生的影响方法: 用丙酸睾酮诱导大鼠前列 腺增生,观察正常对照组模型组低剂量中剂量及高剂量大豆异黄酮组大鼠前列腺的湿重前列腺指数形态 学前列腺特异性酸性磷酸酶及酸性磷酸酶改变结果: 低中高剂量组大鼠前叶前列腺湿重及前列腺指数 前列腺特异性酸性磷酸酶均显著低于模型组( P 0.05) ; 中高剂量组大鼠前叶前列腺湿重及前列腺指数和前 列腺特异性酸性磷酸酶均显著低于低剂量组( P 0.05) 结论:大豆异黄酮可显著抑制大鼠前列腺增生, 抑制酸 性磷酸酶水平的升高, 且呈剂量依赖性大豆异黄酮可能对预防和辅助治疗良性前列腺增生有 一定作用 [] 营养学; 黄豆; 异黄酮类; 前列腺增生; 大鼠; 酸性磷酸酶 [] R153. 3 [ ] A [ ] 2003) Inhibitive eff ect of soybean isoflavone on prostate hyperplasia in rats REN Guofeng,HUANG iming ( Dep artment of N utrition and Food Hygiene, S chool of Public Health, Central S outh Univ ersity , Chang sha 410078, China) Abstract: Objective To explorethe inhibitive effect of soybean isoflavoneon benign prostatic hyperplasia in rats. Methods By subcutaneously injecting testosterone propionateto induce prostate hyperplasia in rats, the changes of prostate wet weight, prostatic index, morphological change, prostatespecific acid phosphatase ( PAP) , acid phosphatase in the control,the model,low, moderate, high dose of soybean isoflavone groups were observed. Results The ventral prostate wet weight, prostatic index, and PAP in the low, moderate, and high dose groups were significantly lower than those in the models ( P 0.05) . The ventral prostate wet weight, prostatic index, and PAP in the moderate, and high dose groups were significantly lower than those in the low dose group ( P 0. 05) . Conclusion Soybean isoflavone inhibits prostate hyperplasia and the increase of acid phos phatase and PAP in a dosedependent manner in rats. Soybean isoflavone may serve as supplementary therapy and prevent benign prostatic hyperplasia.