右美托咪定对腰椎融合术围术期炎症因子的影响.docVIP

右美托咪定对腰椎融合术围术期炎症因子的影响 黄小静 姚军 尚嘉伟 黄同飞 汪正平 【摘要】 目的方法g·kg-1，对照组（生理盐水组）给予生理盐水。比较两组麻醉诱导前（T0）、给予右美托咪定后（T1）、给药30min后（T2）时的术中平均动脉压（MAP）、心率（HR）；比较两组术中术后麻醉镇痛药用量。于麻醉诱导前（T0）、手术结束时（T3）、术后18～20h（T4）时抽取静脉血，酶联免疫法（ELISA）测定促炎因子高迁移率族蛋白B1（HMGB1）、白介素-6（IL-6）、核因子-κB（NF-κB），抗炎因子白介素-10（IL-10）结果0.05）；两组之间各时间点NF-κB、HMGB1、IL-10的水平无统计学差异（P值均＞0.05）；与T0时间点相比较，右美托咪定组与生理盐水组的MAP、HR均有下降（P值均＜0.05），但两组之间无统计学差异（P值均＞0.05）；两组之间麻醉性镇痛药用量无统计学差异（P值均＞0.05）。结论NF-κB、IL-10无明显影响。 【关键词a2肾上腺素能受体；腰椎融合术 作者单位：200080 上海，上海交通大学附属第一人民医院麻醉科（黄小静），上海交通大学附属第六人民医院麻醉科（姚军、尚嘉伟、黄同飞），同济大学附属第十人民医院麻醉科（汪正平） 通信作者：汪正平，电子信箱为wangzpli@ Effects of dexmedetomidine on in?ammatory responses in patients undergoing lumbar spinal fusion *HUANG Xiaojing, YAO Jun, SHANG Jiawei, HUANG Tongfei, WANG Zhengping. *Department of Anesthesiology, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, China Corresponding author: WANG Zhengping. E-mail: wangzpli@ 【Abstract】 Objective The aim of this study was to document the effects of dexmedetomidine on perioperative inflammatory responses. Methods Patients undergoing lumbar spinal fusion were enrolled. After induction of anaesthesia, patients in the dexmedetomidine group (n = 30, group D) received a loading dose of dexmedetomidine (0.75μg·kg-1). A saline-treated group (n = 30, group S) served as a control. Intraoperative mean arterial pressure (MAP), heart rate (HR) were compared between the groups at three times: before anaesthesia induction (T0), at the end of the administration of DEX (T1), and 30min after the administration of DEX (T2); and amount of rescue analgesic administered as post-anaesthetic care were compared between the groups. The pro-inflammatory cytokines high mobility group box 1(HMGB1), interleukin (IL)-6, and nuclear factor (NF)-kB, and anti-inflammatory cytokines IL-10 were quantified by sandwich enzyme-linked immunoassay at three times: before anaesthesia induction (T0), at the end of surgry (T3), and 18-20 hour after surgery (T4). Results At