鼻咽癌奈达铂和顺铂诱导化疗的疗效比较2.docVIP

奈达铂或顺铂联合5-氟尿嘧啶1,2，张爱兰1,2，马文娟1,2，黄培钰1,2，罗东华1,2，夏伟雄1,2 1.华南肿瘤学国家重点实验室，广东 广州 510060 2.中山大学肿瘤防治中心鼻咽科，广东 广州 510060 【摘要】目的：比较奈达铂联合5-氟尿嘧啶氟尿嘧啶氟尿嘧啶氟尿嘧啶χ2检验比较两组患者的疗效和急性毒副反应。结果：所有患者均可作疗效评价，两组病例的临床资料比较无明显差别。NF组和PF组肿瘤全消各3例。NF组的有效率为86％，PF组为84％χ2 =0.078, P=0.779）。PF组恶心呕吐的发生率明显高于NF组（88% vs. 56%，χ2 =23.268, P=0.000）。两组外周血白细胞数、血小板数、谷丙转氨酶、尿素氮和肌酐异常的发生率比较无显著差异（P0.05）。结论：奈达铂联合5－FU是治疗局部中晚期鼻咽癌的有效方案，可取得与PF方案相似的有效率，在减少恶心呕吐方面显示明显的优势。 【关键词】鼻咽肿瘤；奈达铂；化学疗法；顺铂 基金项目：“十一五”国家科技重大专项2008ZX09312-002） Grant: Major science and technology project of National Significant new drug creation (No.2008ZX09312-002) Nedaplatin or cisplatin combined with 5-fluorouracil for treatment of stage Ⅲ-Ⅳa nasopharyngeal carcinoma: a randomized controlled study CAO Ka-jia1,2, ZHANG Ai-lan1,2, MA Wen-juan1,2, HUANG Pei-yu1,2, LUO Dong-hua1,2, XIA Wei-xiong1,2 1.State Key Laboratory of Oncology in South China，Guangzhou, Guangdong, 510060, P.R. China 2.Department of Nasopharyngeal Cancer, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R. China 【Abstract】Objective: This study was conducted to compare the efficacy and side effects of nedaplatin plus 5-fluorouracil (5-FU) and cisplatin plus 5-FU for treatment of stage Ⅲ-Ⅳa nasopharyngeal carcinoma (NPC). Materials: A total of 100 patients with NPC proved by pathohistology were divided into nedaplatin plus 5-FU group (NF group) and cisplatin plus 5-FU group (PF group): 50 cases in each group. NF group: nedaplatin 30mg/m2, d1-3, 5-FU 750mg/m2 d1-5, repeated every 3 weeks for 2 cycles. PF group: cisplatin 30mg/m2 d1-3, 5-FU 750mg/m2 d1-5, repeated every 3 weeks for 2 cycles. χ2 test was used to compare the efficacy and side-effects of two groups. Result: One hundred patients were evaluable and clinical data in two groups were comparable. Six patients with complete response were observed, 3 cases in NF group and 3 in PF group. The overall response rates were 86% in NF group and 84% in PF group, with no significant difference (χ2 =0.078, P=0.779). The