deleterious effects of high dose connexin 43 mimetic peptide infusion after cerebral ischaemia in near-term fetal sheep高剂量的毒害效应联接蛋白43性脑缺血后注入模拟肽在短期内胎儿羊.pdfVIP

Int. J. Mol. Sci. 2012, 13, 6303-6319; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Deleterious Effects of High Dose Connexin 43 Mimetic Peptide Infusion After Cerebral Ischaemia in Near-Term Fetal Sheep 1 2 3 1 Joanne O. Davidson , Colin R. Green , Louise F. B. Nicholson , Laura Bennet and Alistair J. Gunn 1,* 1 Department of Physiology, The University of Auckland, Auckland 1023, New Zealand; E-Mails: joanne.davidson@auckland.ac.nz (J.O.D.); l.bennet@auckland.ac.nz (L.B.) 2 Department of Ophthalmology, The University of Auckland, Auckland 1023, New Zealand; E-Mail: c.green@auckland.ac.nz 3 Department of Anatomy, The University of Auckland, Auckland 1023, New Zealand; E-Mail: lfb.nicholson@auckland.ac.nz * Author to whom correspondence should be addressed; E-Mail: aj.gunn@auckland.ac.nz; Tel.: +64-09-923-6763; Fax: +64-09-923-1111. Received: 9 April 2012; in revised form: 8 May 2012 / Accepted: 14 May 2012 / Published: 22 May 2012 Abstract: Hypoxic-ischaemic brain injury at birth is associated with 1–3/1000 cases of moderate to severe encephalopathy. Previously, we have shown that connexin 43 hemichannel blockade, with a specific mimetic peptide, reduced the occurrence of seizures, improved recovery of EEG power