deletion of il-4rα on cd4 t cells renders balbc mice resistant to leishmania major infection删除il-4rα的cd4 t细胞呈现balbc小鼠抗利什曼虫主要感染.pdfVIP

Deletion of IL-4Ra on CD4 T Cells Renders BALB/c Mice Resistant to Leishmania major Infection 1[ 1[ 1 1,2 1 1 Magdalena Radwanska , Antony J. Cutler , J. Claire Hoving , Stefan Magez , Christoph Holscher , Andreas Bohms , 1 1 3 4 5 1* Berenice Arendse , Richard Kirsch , Thomas Hunig , James Alexander , Paul Kaye , Frank Brombacher 1 Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 2 VIB, Vrije Universiteit Brussel, Brussels, Belgium, 3 Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany, 4 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom, 5 Immunology and Infection Unit, Department of Biology, University of York, York, United Kingdom Effector responses induced by polarized CD4þ T helper 2 (Th2) cells drive nonhealing responses in BALB/c mice infected with Leishmania major. Th2 cytokines IL-4 and IL-13 are known susceptibility factors for L. major infection in BALB/c mice and induce their biological functions through a common receptor, the IL-4 receptor a chain (IL-4Ra). IL-4Ra– deficient BALB/c mice, however, remain susceptible to L. major infection, indicating that IL-4/IL-13 may induce protective responses. Therefore, the roles of polarized Th2 CD4þ T cells and IL-4/IL-13 responsiveness of non-CD4þ T cells in inducing nonhealer or healer responses have yet to be elucidated. CD4þ T cell–specific IL-4Ra (LckcreIL-4Ra/lox) deficient BALB/c mice were generated and characterized to elucidate