deletion of l-selectin increases atherosclerosis development in apoe？？ mice删除l-selectin增加动脉粥样硬化发展的载脂蛋白e 老鼠.pdfVIP

Deletion of L-Selectin Increases Atherosclerosis Development in ApoE2/ 2 Mice 1,2 1,2 1,2 3 3 Izabela Rozenberg , Susanna H. M. Sluka , Pavani Mocharla , Anders Hallenberg , Pierre Rotzius , ´ 4 ¨ 1,2 1,2,5 2,6 ¨ 1,2,5 Jan Boren , Nicolle Krankel , Ulf Landmesser , Lubor Borsig , Thomas F. Luscher , Einar E. Eriksson3,7, Felix C. Tanner1,2,5* 1 Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland, 2 Center for Integrative Human Physiology, University of Zurich, Zurich, ¨ Switzerland, 3 Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden, 4 Wallenberg Laboratory, Sahlgrenska Academy at Goteborg ¨ ¨ University, Goteborg, Sweden, 5 Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland, 6 Institute of Physiology, University of Zurich, Zurich, Switzerland, 7 Department of Molecular Medicine and Surgery, Karolinska Institute, Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden Abstract Atherosclerosis is an inflammatory disease characterized by accumulation of leukocytes in the arterial intima. Members of the selectin family of adhesion molecules are important mediators of leukocyte