deciphering the role of rnd efflux transporters in burkholderia cenocepacia破译rnd射流在洋葱cenocepacia转运蛋白的作用.pdfVIP
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deciphering the role of rnd efflux transporters in burkholderia cenocepacia破译rnd射流在洋葱cenocepacia转运蛋白的作用
Deciphering the Role of RND Efflux Transporters in Burkholderia cenocepacia 1. 1. 2. 1 3 Silvia Bazzini , Claudia Udine , Andrea Sass , Maria Rosalia Pasca , Francesca Longo , Giovanni 4 5 5 6 6 6 Emiliani , Marco Fondi , Elena Perrin , Francesca Decorosi , Carlo Viti , Luciana Giovannetti , Livia 3 5 1 2 1 Leoni , Renato Fani , Giovanna Riccardi , Eshwar Mahenthiralingam , Silvia Buroni * ` 1 Dipartimento di Genetica e Microbiologia, Universita degli Studi di Pavia, Pavia, Italy, 2 Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom, ` 3 Dipartimento di Biologia, Universita Roma Tre, Roma, Italy, 4 Trees and Timber Institute – National Research Council, San Michele all’Adige, Italy, 5 Department of ` Evolutionary Biology, University of Florence, Firenze, Italy, 6 Dipartimento di Biotecnologie Agrarie, Universita degli Studi di Firenze, Firenze, Italy Abstract Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B. cenocepacia is very difficult with the antimicrobial therapy being ineffective due to its high resistance to clinically relevant antimicrobial agents and disinfectants. RND (Resistance-Nodulation-Cell Division) efflux pumps are kn
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