有哪些信誉好的足球投注网站decreased spontaneous eye blink rates in chronic cannabis users evidence for striatal cannabinoid-dopamine interactions减少自发眨眼率长期吸食大麻的证据纹状体cannabinoid-dopamine交互.pdfVIP
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decreased spontaneous eye blink rates in chronic cannabis users evidence for striatal cannabinoid-dopamine interactions减少自发眨眼率长期吸食大麻的证据纹状体cannabinoid-dopamine交互
Decreased Spontaneous Eye Blink Rates in Chronic Cannabis Users: Evidence for Striatal Cannabinoid- Dopamine Interactions Mikael A. Kowal*, Lorenza S. Colzato, Bernhard Hommel Cognitive Psychology Unit and Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands Abstract Chronic cannabis use has been shown to block long-term depression of GABA-glutamate synapses in the striatum, which is likely to reduce the extent to which endogenous cannabinoids modulate GABA- and glutamate-related neuronal activity. The current study aimed at investigating the effect of this process on striatal dopamine levels by studying the spontaneous eye blink rate (EBR), a clinical marker of dopamine level in the striatum. 25 adult regular cannabis users and 25 non-user controls matched for age, gender, race, and IQ were compared. Results show a significant reduction in EBR in chronic users as compared to non-users, suggesting an indirect detrimental effect of chronic cannabis use on striatal dopaminergic functioning. Additionally, EBR correlated negatively with years of cannabis exposure, monthly peak cannabis consumption, and lifetime cannabis consumption, pointing to a relationship between the degree of impairment of striatal dopaminergic transmission and cannabis consumption history. Citation: Kowal MA, Colzato LS, Hommel B (2011) Decreased Spontaneous Eye Blink Rates in Chronic Cannabis Users: Evidence for Striatal Cannabinoid- Dopamine Interactions. PLoS ONE 6(11): e26662. doi:10.1371/journal.pone.0026662 ´ Editor: Antonio Verdejo Garcıa, University of Granada, Spain Received July 7, 2011; Accepted September 30, 2011; Published November 18, 2011 Copyright: 2011 Kowal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which per
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