decreased premotor cortex volume in victims of urban violence with posttraumatic stress disorder减少运动前区皮层体积与创伤后应激障碍城市暴力的受害者.pdfVIP

Decreased Premotor Cortex Volume in Victims of Urban Violence with Posttraumatic Stress Disorder 1 2 2 2 3 Vanessa Rocha-Rego *, Mirtes G. Pereira , Leticia Oliveira , Mauro V. Mendlowicz , Adriana Fiszman , 3 2 4 1 5 6 Carla Marques-Portella , William Berger , Carlton Chu , Mateus Joffily , Jorge Moll , Jair J. Mari , Ivan Figueira3, Eliane Volchan1 ´ 1 Instituto de Biofısica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 2 Universidade Federal Fluminense, Niteroi, Brazil, 3 Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 4 University College London, London, United Kingdom, 5 D’Or Institute for Research and ˜ ˜ Education, Rio de Janeiro, Brazil, 6 Universidade Federal de Sao Paulo, Sao Paulo, Brazil Abstract Background: Studies addressing posttraumatic stress disorder (PTSD) have demonstrated that PTSD patients exhibit structural abnormalities in brain regions that relate to stress regulation and fear responses, such as the hippocampus, amygdala, anterior cingulate cortex, and ventromedial prefrontal cortex. Premotor cortical areas are involved in preparing to respond to a threatening situation and in representing the peripersonal space. Urban violence is an important and pervasive cause of human suffering, especially in large urban centers in the developing world. Violent events, such as armed robbery, are very frequent in certain cities, and these episod