decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling探索性活动下降15 q复制综合征小鼠模型;.pdfVIP

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decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling探索性活动下降15 q复制综合征小鼠模型;.pdf

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decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling探索性活动下降15 q复制综合征小鼠模型;

Decreased Exploratory Activity in a Mouse Model of 15q Duplication Syndrome; Implications for Disturbance of Serotonin Signaling 1,2,3 1 1,3,4 1,2,3 5,6,7 Kota Tamada , Shozo Tomonaga , Fumiyuki Hatanaka , Nobuhiro Nakai , Keizo Takao , 5,6,7,8 1 1,3,4,8 Tsuyoshi Miyakawa , Jin Nakatani , Toru Takumi * 1 Osaka Bioscience Institute, Suita, Japan, 2 Kyoto University Graduate School of Biostudies, Kyoto, Japan, 3 Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, 4 Kyoto University Graduate School of Medicine, Kyoto, Japan, 5 Frontier Technology Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 6 Division of Systems Medicine, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan, 7 Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Japan, 8 Japan Science and Technology Agent (JST), Core Research for Evolutional Science and Technology (CREST), Saitama, Japan Abstract Autism spectrum disorders (ASDs) have garnered significant attention as an important grouping of developmental brain disorders. Recent genomic studies have revealed that inherited or de novo copy number variations (CNVs) are significantly involved in the pathophysiology of ASDs. In a previous report from our laboratory, we generated mice with CNVs as a model of ASDs, with a duplicated mouse chromosome 7C that is orthologous to human chromosome 15q11-13. Behavioral analyses revealed paternally duplicated (patDp/+) mice displayed abnormal behaviors res