decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction脱细胞基质与galectin-1肿瘤发生的人类间充质干细胞促进新血管形成相关的内皮细胞的相互作用.pdfVIP

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2017-09-12 发布于上海
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decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction脱细胞基质与galectin-1肿瘤发生的人类间充质干细胞促进新血管形成相关的内皮细胞的相互作用.pdf

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decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction脱细胞基质与galectin-1肿瘤发生的人类间充质干细胞促进新血管形成相关的内皮细胞的相互作用

Decellularized Matrix from Tumorigenic Human Mesenchymal Stem Cells Promotes Neovascularization with Galectin-1 Dependent Endothelial Interaction 1,2 1 3 1 3 Jorge S. Burns *, Malthe Kristiansen , Lars P. Kristensen , Kenneth H. Larsen , Maria O. Nielsen , Helle 3 4 3 1,5 Christiansen , Jan Nehlin , Jens S. Andersen , Moustapha Kassem 1 Molecular Endocrinology Laboratory KMEB, Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark, 2 Laboratory of Cell Biology and Advanced Cancer Therapies, Department of Oncology, Hematology and Respiratory Disease, University Hospital of Modena and Reggio Emilia, Modena, Italy, 3 Department of Biochemistry and Molecular Biology, Center for Experimental BioInformatics, University of Southern Denmark, Odense, Denmark, 4 Department of Clinical Immunology, Institute of Clinical Research, Odense, Denmark, 5 Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia Abstract Background: Acquisition of a blood supply is fundamental for extensive tumor growth. We recently described vascular heterogeneity in tumours derived from cell clones of a human mesenchymal stem cell (hMSC) strain (hMSC-TERT20) immortalized by retroviral vector mediated human telomerase (hTERT) gene expression. Histological analysis showed that cells of the most vascularized tumorigenic clone, -BD11 had a pericyte-like alpha smooth muscle actin (ASMA+) and CD146+ positive phenotype. Upon serum withdrawal in culture, -BD11 cells formed cord-like structures mimic