decellularized tendon extracellular matrix—a valuable approach for tendon reconstruction脱细胞肌腱细胞外肌腱重建矩阵a有价值的方法.pdfVIP

Cells 2012, 1, 1010-1028; doi:10.3390/cells1041010 OPEN ACCESS cells ISSN 2073-4409 /journal/cells Review Decellularized Tendon Extracellular MatrixA Valuable Approach for Tendon Reconstruction? Gundula Schulze-Tanzil *, Onays Al-Sadi, Wolfgang Ertel and Anke Lohan Department of Orthopaedic, Trauma and Reconstructive Surgery, Campus Benjamin Franklin, Charité-University of Medicine Berlin, Garystrasse 5, Berlin 14195, Germany; E-Mails: onays.al-sadi@charite.de (O.A.-S.); wolfgang.ertel@charite.de (W.E.); anke.lohan@charite.de (A.L.) * Author to whom correspondence should be addressed; E-Mail: gundula.schulze-tanzil@charite.de; Tel.: +49-30-552-385; Fax: +49-30-552-985. Received: 17 August 2012; in revised form: 18 October 2012 / Accepted: 25 October 2012 / Published: 5 November 2012 Abstract: Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or xenogenic tendon extracellular matrix (ECM) have recently started to attract interest. This ECM combines the advantages of its intrinsic mechanical competence with that of providing tenogenic stimuli for immigrating cells mediated, for example, by the growth factors and ot