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Coverage, Adherence and Costs of Intermittent Preventive Treatment of Malaria in Children Employing Different Delivery Strategies in Jasikan, Ghana 1 2 1 3 1 Edith Patouillard *, Lesong Conteh , Jayne Webster , Margaret Kweku , Daniel Chandramohan , Brian Greenwood1 1 Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, England, 2 Institute of Global Health Innovation, Imperial College London, London, England, 3 Ghana Health Service, University of Ghana, Accra, Ghana Abstract Background: Intermittent preventive treatment of malaria in children (IPTc) involves the administration of a course of anti- malarial drugs at specified time intervals to children at risk of malaria regardless of whether or not they are known to be infected. IPTc provides a high level of protection against uncomplicated and severe malaria, with monthly sulphadoxine- pyrimethamine plus amodiaquine (SPAQ) and sulphadoxine-pyrimethamine plus piperaquine being the most efficacious regimens. A key challenge is the identification of a cost-effective delivery strategy. Methods: A community randomized trial was undertaken in Jasikan district, Ghana to assess IPTc effectiveness and costs using SPAQ delivered in three different ways. Twelve villages were randomly selected to receive IPTc from village health workers (VHWs) or facility-based nurses working at health centres’ outpatient departments (OPD) or EPI outreach clinics. Children aged 3 to 59 months-old received one IPT course (three doses) in May, June, September and October. Effectiveness was measured in terms of children covered and adherent to a course and delivery costs were calculated in financial and economic terms using an ingredient approach from the provider perspective.