deciphering the interleukin 28b variants that better predict response to pegylated interferon-α and ribavirin therapy in hcvhiv-1 coinfected patients破译白介素28 b变种,更好地预测聚乙二醇interferon-α和利巴韦林治疗hcvhiv-1合并感染患者.pdfVIP

下载本文档

0
0
约4.23万字
约 5页
2017-11-22 发布于上海
举报
版权申诉

deciphering the interleukin 28b variants that better predict response to pegylated interferon-α and ribavirin therapy in hcvhiv-1 coinfected patients破译白介素28 b变种,更好地预测聚乙二醇interferon-α和利巴韦林治疗hcvhiv-1合并感染患者.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

deciphering the interleukin 28b variants that better predict response to pegylated interferon-α and ribavirin therapy in hcvhiv-1 coinfected patients破译白介素28 b变种,更好地预测聚乙二醇interferon-α和利巴韦林治疗hcvhiv-1合并感染患者

Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-a and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients 1 1 1 1 2 Montserrat de Castellarnau , Ester Aparicio , Mariona Parera , Sandra Franco , Cristina Tural , 1,2 ´ 1 Bonaventura Clotet , Miguel Angel Martınez * ´ ´ 1 Fundacio irsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain, 2 Fundacio de la Lluita contra la Sida, Hospital Universitari Germans Trias i Pujol, Badalona, Spain Abstract Previous works have documented the contribution of different IL28B-associated SNPs to spontaneous HCV clearance. This study investigated the effect of different interleukin (IL) 28B genetic variants on interferon (IFN)-based therapy response. We genotyped eight IL28B single-nucleotide polymorphisms (SNPs) in a cohort of 197 hepatitis C virus (HCV)/human immunodeficiency virus type 1 (HIV-1) coinfected patients from our clinic unit who received combined pegylated (peg)-IFN- a and ribavirin (RBV) therapy. This analysis included the two strongest tag predictors for HCV clearance, rs8099917 and r and four causal variants (rs4803219, r rs8103142, and rs4803217) located in the IL28B promoter, coding, and 39-untranslated regions. Haplotypes carrying the major alleles at IL28B SNPs were highly associated with sustained virological responses (SVRs) after treatment with peg-IFN-a and RBV [od