有哪些信誉好的足球投注网站decay kinetics of an interferon gamma release assay with anti-tuberculosis therapy in newly diagnosed tuberculosis cases衰减动力学的干扰素释放试验和抗结核治疗新诊断结核病病例.pdfVIP
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decay kinetics of an interferon gamma release assay with anti-tuberculosis therapy in newly diagnosed tuberculosis cases衰减动力学的干扰素释放试验和抗结核治疗新诊断结核病病例
Decay Kinetics of an Interferon Gamma Release Assay with Anti-Tuberculosis Therapy in Newly Diagnosed Tuberculosis Cases 1 1 2 1 Ifedayo M. O. Adetifa *, Martin O. C. Ota , Brigitte Walther , Abdulrahman S. Hammond , Moses D. 1 2 1 1 1 Lugos , David J. Jeffries , Simon A. Donkor , Richard A. Adegbola , Philip C. Hill 1 Bacterial Diseases Programme, Medical Research Council (United Kingdom) Laboratories, Fajara, The Gambia, 2 Statistics and Data Support Unit, Medical Research Council (United Kingdom) Laboratories, Fajara, The Gambia Abstract Background: Qualitative and quantitative changes in IGRA response offer promise as biomarkers to monitor Tuberculosis (TB) drug therapy, and for the comparison of new interventions. We studied the decay kinetics of TB-specific antigen T-cell responses measured with an in-house ELISPOT assay during the course of therapy. Methods: Newly diagnosed sputum smear positive TB cases with typical TB chest radiographs were recruited. All patients were given standard anti-TB treatment. Each subject was followed up for 6 months and treatment outcomes were documented. Blood samples were obtained for the ESAT-6 and CFP-10 (EC) ELISPOT at diagnosis, 1-, 2-, 4- and 6-months. Qualitative and quantitative reversion of the ELISPOT results were assessed with McNemar test, conditional logistic regression and mixed-effects hierarchical Poisson models. Results: A total of 116 cases were recruited and EC ELISPOT was positive for 87% (95 of 109) at recruitment. There was a significant decrease in the proportion of EC ELISPOT positive ca
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