cytotoxic terpene quinones from marine sponges从海绵中细胞毒性萜醌类.pdfVIP

Mar. Drugs 2010, 8, 2849-2870; doi:10.3390/md8122849 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Cytotoxic Terpene Quinones from Marine Sponges Marina Gordaliza Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, 37007 Salamanca, Spain; E-Mail: mliza@usal.es; Tel.: +34-923-294-528; Fax: +34-923-294-515 Received: 7 October 2010; in revised form: 12 November 2010 / Accepted: 17 November 2010 / Published: 24 November 2010 Abstract: The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives. Keywords: terpene quinone; terpene hydroquinone; avarone; avarol; cytotoxicity 1. Introduction The few therapeutic novelties of synthetic origin that have appeared on the pharmaceutical market, of which more than 88% are based on preexisting structures, have flooded the pharmaceutical world with very similar products. This has led to a new and enthusiastic retrospective appraisal o