coreceptor and cytokine concentrations may not explain differences in disease progression observed in hiv-1 clade a and d infected ugandanscoreceptor和细胞因子浓度可能不会解释不同的疾病进展中观察到分支a和d的hiv - 1感染的乌干达人.pdfVIP

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coreceptor and cytokine concentrations may not explain differences in disease progression observed in hiv-1 clade a and d infected ugandanscoreceptor和细胞因子浓度可能不会解释不同的疾病进展中观察到分支a和d的hiv - 1感染的乌干达人.pdf

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coreceptor and cytokine concentrations may not explain differences in disease progression observed in hiv-1 clade a and d infected ugandanscoreceptor和细胞因子浓度可能不会解释不同的疾病进展中观察到分支a和d的hiv - 1感染的乌干达人

Coreceptor and Cytokine Concentrations May Not Explain Differences in Disease Progression Observed in HIV-1 Clade A and D Infected Ugandans 1,2 1 3 1 1 Edward Wright *, Susan Mugaba , Paul Grant , Rosalind Parkes-Ratanshi , Lieve Van der Paal , Heiner Grosskurth1,4, Pontiano Kaleebu1,4 1 MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute (UVRI), Entebbe, Uganda, 2 Division of Infection and Immunity, University College London, London, United Kingdom, 3 Department of Virology, University College London Hospital, London, United Kingdom, 4 London School of Hygiene and Tropical Medicine, London, United Kingdom Abstract Background: The use of cellular coreceptors and modulation of cytokine concentrations by HIV to establish a productive infection is well documented. However, it is unknown whether the expression of these proteins affects the course of HIV clade A and D disease, reported to have different progression rates. Methodology/Principal Findings: We investigated whether the number of CD4+ T-cells expressing CCR5 or CXCR4, the density of these coreceptors and concentrations of specific immune proteins linked to HIV pathogenesis vary between individuals infected with HIV clade A or D. We undertook additional analyses stratifying participants by early (CD4.500 cells/ml) or late (CD4,200 cells/ml) disease stage. Whole blood samples were taken from 50 HIV-1 infected individuals drawn from cohorts in rural south-west Uganda. Late stage participants had less than half the number of CD4+/CCR5+ T-cells (p = 0.0113) and 5.6 times fewer CD4+/CXCR4+ cells (p,0.0001) than early stage participants. There was also a statistically significant d