有哪些信誉好的足球投注网站cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone a prospective, longitudinal study细胞因子白细胞生产的军事人员部署到战区后与抑郁症状前瞻性纵向研究.pdfVIP
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cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone a prospective, longitudinal study细胞因子白细胞生产的军事人员部署到战区后与抑郁症状前瞻性纵向研究
Cytokine Production by Leukocytes of Military Personnel with Depressive Symptoms after Deployment to a Combat-Zone: A Prospective, Longitudinal Study 1,2 1 3 1 1 Mirjam van Zuiden , Cobi J. Heijnen , Rens van de Schoot , Karima Amarouchi , Mirjam Maas , Eric 2,4 2,4 1 Vermetten , Elbert Geuze , Annemieke Kavelaars * 1 Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center, Utrecht, Utrecht, the Netherlands, 2 Research Centre – Military Mental Health, Ministry of Defence, Utrecht, the Netherlands, 3 Department of Methodology and Statistics, Faculty of Social Sciences, Utrecht University, Utrecht, the Netherlands, 4 Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands Abstract Major depressive disorder (MDD) is frequently diagnosed in military personnel returning from deployment. Literature suggests that MDD is associated with a pro-inflammatory state. To the best of our knowledge, no prospective, longitudinal studies on the association between development of depressive symptomatology and cytokine production by peripheral blood leukocytes have been published. The aim of this study was to investigate whether the presence of depressive symptomatology six months after military deployment is associated with the capacity to produce cytokines, as assessed before and after deployment. 1023 military personnel were included before deployment. Depressive symptoms and LPS- and T-cell mitogen-induced production of 16 cytokines and chemokines in whole blood cultures were measured before (T0), 1 (T1), and 6 (T2) mont
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