有哪些信誉好的足球投注网站cxcl12 mediates trophic interactions between endothelial and tumor cells in glioblastomacxcl12调节营养胶质母细胞瘤中内皮细胞和肿瘤细胞之间的相互作用.pdfVIP
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cxcl12 mediates trophic interactions between endothelial and tumor cells in glioblastomacxcl12调节营养胶质母细胞瘤中内皮细胞和肿瘤细胞之间的相互作用
CXCL12 Mediates Trophic Interactions between Endothelial and Tumor Cells in Glioblastoma 1. 2. 2 2 3,4 2 Shyam Rao , Rajarshi Sengupta , Eun Joo Choe , B. Mark Woerner , Erin Jackson , Tao Sun , Jeffrey Leonard5, David Piwnica-Worms3,4,6,7, Joshua B. Rubin2,8* 1 Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 3 Bridging Research with Imaging, Genomics and High-Throughput Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 5 Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, United States of America, 6 Department of Cell Biology Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 7 Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 8 Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America Abstract Emerging evidence suggests endothelial cells (EC) play a critical role in promoting Glioblastoma multiforme (GBM) cell proliferation and resistance to therapy. The molecular basis for GBM-EC interactions is incompletely understood. We hypothesized that the chemokine CXCL12 and its receptor CXCR4 could mediate direct interactions between GBM cells and tumor-asso
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