convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms趋同进化染色体决定性别的地区的动物和真菌的王国.pdfVIP

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convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms趋同进化染色体决定性别的地区的动物和真菌的王国.pdf

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convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms趋同进化染色体决定性别的地区的动物和真菌的王国

Open access, freely available online PLoS BIOLOGY Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms 1,2 1,3 1 1,3 1,2¤ 1,3 James A. Fraser , Stephanie Diezmann , Ryan L. Subaran , Andria Allen , Klaus B. Lengeler , Fred S. Dietrich , Joseph Heitman1,2,4,5* 1 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, 2 Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America, 3 Duke Institute for Genomics Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America, 4 Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, 5 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region. We hypothesize that MAT evolved via four main steps, beginning with acquisition of genes into two unlinked sex-determining regions, forming independent gene clusters that then fused via chromosomal translocation. A transitional tripolar intermediate state then converted to a bipolar system via gene conversion or recombination between the linked and unlinked sex-determining regions. MAT was subsequently subjected to intra- an