current perspectives on desmoid tumors the mayo clinic approach当前观点硬纤维瘤mayo诊所的方法.pdfVIP

Cancers 2011, 3, 3143-3155; doi:10.3390/cancers3033143 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Current Perspectives on Desmoid Tumors: The Mayo Clinic Approach 1 2 2, 3 4 Siddharth B. Joglekar , Peter S. Rose , Franklin Sim *, Scott Okuno and Ivy Petersen 1 Musculoskeletal Oncology, Mayo Clinic, Rochester, MN55905, USA; E-Mail: joglekar.siddharth@ 2 st Department of Orthopedics, Mayo Clinic, 200 1 ST SW, Rochester, MN 55905, USA; E-Mail: rose.peter@ 3 Department of Oncology, Mayo Clinic, Rochester, MN55905, USA; E-Mail: okuno.scott@ 4 Department of Radiation Oncology, Mayo Clinic, Rochester, MN55905, USA; E-Mail: petersen.ivy@ * Author to whom correspondence should be addressed; E-Mail: sim.franklin@; Tel.: +1-507 284 8314. Received: 30 May 2011; in revised form: 6 July 2011 / Accepted: 2 August 2011 / Published: 8 August 2011 Abstract: Desmoid tumors are a rare group of locally aggressive, non malignant tumors of fibroblastic origin that can lead to significant morbidity due to local invasion. Despite advances in the understanding of these tumors, their natural history is incompletely understood and the optimal treatment is still a matter of debate. Local control is the main goal of treatment and there has been a change in philosophy regarding the management