有哪些信誉好的足球投注网站cspg is a secreted factor that stimulates neural stem cell survival possibly by enhanced egfr signalingcspg分泌因子,刺激神经干细胞存活可能通过增强表皮生长因子受体信号.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
cspg is a secreted factor that stimulates neural stem cell survival possibly by enhanced egfr signalingcspg分泌因子,刺激神经干细胞存活可能通过增强表皮生长因子受体信号
CSPG Is a Secreted Factor that Stimulates Neural Stem Cell Survival Possibly by Enhanced EGFR Signaling Muly Tham, Srinivas Ramasamy, Hui Theng Gan, Ashray Ramachandran, Anuradha Poonepalli, Yuan Hong Yu, Sohail Ahmed* Neural Stem Cell Laboratory, Institute of Medical Biology, Singapore, Singapore Abstract Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors (NPs) as neurospheres (nsphs). The nsph conditioned medium (nsph-CM) contains cell- secreted factors that can regulate NSC behavior. However, the identity and exact function of these factors within the nsph- CM has remained elusive. We analyzed the nsph-CM by mass spectrometry and identified DSD-1-proteoglycan, a chondroitin sulfate proteoglycan (CSPG), apolipoprotein E (ApoE) and cystatin C as components of the nsph-CM. Using clonal assays we show that CSPG and ApoE are responsible for the ability of the nsph-CM to stimulate nsph formation whereas cystatin C is not involved. Clonal nsphs generated in the presence of CSPG show more than four-fold increase in NSCs. Thus CSPG specifically enhances the survival of NSCs. CSPG also stimulates the survival of embryonic stem cell (ESC)- derived NSCs, and thus may be involved in the developmental transition of ESCs to NSCs. In addition to its role in NSC survival, CSPG maintains the three dimensional structure of nsphs. Lastly, CSPG’s effects on NSC survival may be mediated by enhanced signaling via EGFR, JAK/STAT3 and PI3K/Akt pathways. Citation: Tham M, Ramasamy S, Gan HT, Ramachandran A, Poonepalli A, et al. (2010) CSPG Is a Secreted Factor that Stimulates Neural Stem C
您可能关注的文档
- control of kaposi's sarcoma-associated herpesvirus reactivation induced by multiple signals控制卡波济氏肉瘤相关疱疹病毒再活化诱导由多个信号.pdf
- controlling pandemic flu the value of international air travel restrictions控制流感国际航空旅行限制的价值.pdf
- controlling effects of irradiance and heterotrophy on carbon translocation in the temperate coral cladocora caespitosa对碳排放控制辐照度的影响和异养易位在温和的珊瑚cladocora丛生.pdf
- controlling morphological parameters of anodized titania nanotubes for optimized solar energy applications控制阳极氧化二氧化钛纳米管的形态参数优化太阳能应用.pdf
- controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring控制ultrasound-induced血脑屏障破坏使用被动声学排放监测.pdf
- controlling population evolution in the laboratory to evaluate methods of historical inference在实验室控制人口发展历史推理的评估方法.pdf
- controversies and generational differences young people’s identities in some european states争议和代际差异在一些欧洲国家年轻人的身份.pdf
- controlling the response predictive modeling of a highly central, pathogen-targeted core response module in macrophage activation控制的响应预测建模一个高度中央,在巨噬细胞激活pathogen-targeted核心响应模块.pdf
- controls on coral-ground development along the northern mesoamerican reef tract控制沿着中美洲北部礁珊瑚地发展.pdf
- control of transcription by cell size的转录控制细胞的大小.pdf
- cutaneous hpv23 e6 prevents p53 phosphorylation through interaction with hipk2皮肤hpv23 e6防止p53与hipk2磷酸化通过交互.pdf
- current status of antibiograms of listeria ivanovii and enterobacter cloacae isolated from ready-to-eat foods in alice, south africa现状李斯特菌的抗菌谱ivanovii和肠杆菌泄殖腔孤立即食食品的爱丽丝,南非.pdf
- cuticular compounds bring new insight in the post-glacial recolonization of a pyrenean area deutonura deficiens deharveng, 1979 complex, a case study表皮化合物带来新的见解的幅度大开拓殖民地的比利牛斯山脉的地区deutonura deficiens deharveng,1979复杂,一个案例研究.pdf
- cutting a drop of water pinned by wire loops using a superhydrophobic surface and knife减少线的一滴水固定循环使用超疏水表面和刀.pdf
- cxcl12 and [n33a]cxcl12 in 5637 and hela cells regulating her1 phosphorylation via calmodulincalcineurincxcl12和[n33a]cxcl12和5637年海拉细胞调节通过calmodulincalcineurin her1磷酸化.pdf
- curvature entropy for curved profile generation为弯曲曲率熵概要文件生成.pdf
- curvature of double-membrane organelles generated by changes in membrane size and composition曲率变化产生的双层膜细胞器膜的大小和构成.pdf
- cxcr3 antagonism of sdf-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertensioncxcr3 sdf-1拮抗作用(5 - 67)恢复小梁功能和防止视网膜神经退化在眼部的高血压大鼠模型.pdf
- cxcl12 mediates trophic interactions between endothelial and tumor cells in glioblastomacxcl12调节营养胶质母细胞瘤中内皮细胞和肿瘤细胞之间的相互作用.pdf
- cwm global search—the internet search engine for chemists and biologists化学家和生物学家的cwm全球有哪些信誉好的足球投注网站互联网有哪些信誉好的足球投注网站引擎.pdf
文档评论（0）