有哪些信誉好的足球投注网站curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase d1姜黄素变弱β-catenin信号在前列腺癌细胞通过激活蛋白激酶d1.pdfVIP
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curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase d1姜黄素变弱β-catenin信号在前列腺癌细胞通过激活蛋白激酶d1
Curcumin Attenuates b-catenin Signaling in Prostate Cancer Cells through Activation of Protein Kinase D1 1 1,2 1 1,2 Vasudha Sundram , Subhash C. Chauhan , Mara Ebeling , Meena Jaggi * 1 Cancer Biology Research Center, Sanford Research/USD, Sioux Falls, South Dakota, United States of America, 2 Department of OB/GYN and Basic Biomedical Science Division, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota, United States of America Abstract Prostate cancer is the most commonly diagnosed cancer affecting 1 in 6 males in the US. Understanding the molecular basis of prostate cancer progression can serve as a tool for early diagnosis and development of novel treatment strategies for this disease. Protein Kinase D1 (PKD1) is a multifunctional kinase that is highly expressed in normal prostate. The decreased expression of PKD1 has been associated with the progression of prostate cancer. Therefore, synthetic or natural products that regulate this signaling pathway can serve as novel therapeutic modalities for prostate cancer prevention and treatment. Curcumin, the active ingredient of turmeric, has shown anti-cancer properties via modulation of a number of different molecular pathways. Herein, we have demonstrated that curcumin activates PKD1, resulting in changes in b- catenin signaling by inhibiting nuclear b-catenin transcription activity and enhancing the levels of membrane b-catenin in prostate cancer cells. Modulation of these cellular events by curcumin correlated with decreased cell proliferation, colony formation and cell motility and enhanced cell-cell aggregation in prostate cancer cells. In addition, we have also revealed that inhi
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