有哪些信誉好的足球投注网站control of parasitophorous vacuole expansion by lystbeige restricts the intracellular growth of leishmania amazonensis控制parasitophorous泡扩张lystbeige限制利什曼虫的细胞内增长amazonensis.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
control of parasitophorous vacuole expansion by lystbeige restricts the intracellular growth of leishmania amazonensis控制parasitophorous泡扩张lystbeige限制利什曼虫的细胞内增长amazonensis
Control of Parasitophorous Vacuole Expansion by LYST/ Beige Restricts the Intracellular Growth of Leishmania amazonensis 1. 1. 2 3 3 2 Jude Wilson , Chau Huynh , Kathleen A. Kennedy , Diane M. Ward , Jerry Kaplan , Alan Aderem , Norma W. Andrews4* 1 Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America, 2 Institute for Systems Biology, Seattle, Washington, United States of America, 3 Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America, 4 Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, United States of America Abstract The intracellular protozoan Leishmania replicates in parasitophorous vacuoles (PV) that share many features with late endosomes/lysosomes. L. amazonensis PVs expand markedly during infections, but the impact of PV size on parasite intracellular survival is still unknown. Here we show that host cells infected with L. amazonensis upregulate transcription of LYST/Beige, which was previously shown to regulate lysosome size. Mutations in LYST/Beige caused further PV expansion and enhanced L. amazonensis replication. In contrast, LYST/Beige overexpression led to small PVs that did not sustain parasite growth. Treatment of LYST/Beige over-expressing cells with vacuolin-1 reversed this phenotype, expanding PVs and promoting parasite growth. The opposite was seen with E-64d, which reduced PV size in LYST-Beige mutant cells and inhibited L. amazonensis replication. Enlarged PVs appear to protect parasites from oxidative damage, since inhibition of nitric oxide synth
您可能关注的文档
- comparison of two methods for in vivo estimation of the glenohumeral joint rotation center (gh-jrc) of the patients with shoulder hemiarthroplasty比较两种方法的体内盂肱关节旋转中心的估计(gh-jrc)患者肩膀心脏血管.pdf
- comparison of ultrasonic and co2 laser pretreatment methods on enzyme digestibility of corn stover比较超声和二氧化碳激光预处理对玉米秸秆酶消化方法.pdf
- comparison of standard 1.5 t vs. 3 t optimized protocols in patients treated with glatiramer acetate. a serial mri pilot study比较标准的1.5吨和3 t优化协议与醋酸glatiramer患者。.pdf
- compartmentalization of aquaporins in the human intestine水通道蛋白在人类肠道的划分.pdf
- comparisons of three methods for organic and inorganic carbon in calcareous soils of northwestern china比较三种方法的有机和无机碳在中国西北地区石灰性土壤.pdf
- comparison of three targeted enrichment strategies on the solid sequencing platform比较三个目标浓缩固体测序平台的策略.pdf
- comparison of venous and capillary differential leukocyte counts using a standard hematology analyzer and a novel microfluidic impedance cytometer比较静脉和毛细血管微分使用标准的血液学分析仪白细胞计数和一种新型微流控阻抗血细胞计数器.pdf
- compensatory evolution of net-charge in influenza a virus hemagglutinin补偿进化甲型流感病毒血凝素的净电荷.pdf
- compensatory growth impairs adult cognitive performance补偿性增长影响成人的认知能力.pdf
- comparison of two commercial pcr methods for methicillin-resistant staphylococcus aureus (mrsa) screening in a tertiary care hospital比较两个商业pcr方法对耐甲氧西林金黄色葡萄球菌(mrsa)在三级保健医院筛查.pdf
- control of gastric h,k-atpase activity by cations, voltage and intracellular ph analyzed by voltage clamp fluorometry in xenopus oocytes控制胃h,k-atpase活动通过阳离子,电压和细胞内的ph值分析了电压钳位在非洲爪蟾蜍卵母细胞荧光测定术.pdf
- control of centrin stability by aurora a控制centrin稳定的极光.pdf
- control of porosity and pore size of metal reinforced carbon nanotube membranes控制孔隙度和孔隙大小的金属增强碳纳米管膜.pdf
- control of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells控制前体的成熟和处置是一个早期的调控机制在正常胰岛素的胰腺β-cells的生产.pdf
- control of the c. albicans cell wall damage response by transcriptional regulator cas5控制白念珠菌细胞壁破坏反应转录监管机构cas5.pdf
- control of stochastic gene expression by host factors at the hiv promoter随机控制基因表达的宿主因素艾滋病毒启动子.pdf
- control of neural stem cell survival by electroactive polymer substrates控制电活性聚合物基质的神经干细胞的生存.pdf
- control of phage bxb1 excision by a novel recombination directionality factor由新型复合控制噬菌体bxb1切除方向性因素.pdf
- control of viremia and prevention of aids following immunotherapy of siv-infected macaques with peptide-pulsed blood病毒血症的控制和预防艾滋病与peptide-pulsed siv-infected猕猴的免疫治疗后血.pdf
- control of pre-mrna splicing by the general splicing factors puf60 and u2af65控制pre-mrna通用剪接因子puf60和u2af65拼接.pdf
文档评论（0）