curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through janus kinase-stat3 signalling pathway姜黄素块小细胞肺癌细胞迁移、入侵、血管生成、细胞周期和肿瘤通过janus kinase-stat3信号通路.pdfVIP

Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway 1 1 1 2 1 1 3 Cheng-Liang Yang , Yong-Yu Liu *, Ye-Gang Ma , Yi-Xue Xue , De-Gui Liu , Yi Ren , Xiao-Bai Liu , Yao Li2, Zhen Li4 1 Department of Thoracic Surgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning Province, China, 2 Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, Liaoning Province, China, 3 The 96th Class, 7-year Program, China Medical University, Shenyang, Liaoning Province, China, 4 Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China Abstract Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about its anti-tumor mechanism in small cell lung cancer (SCLC). In this study, we found that curcumin can inhibit SCLC cell proliferation, cell cycle, migration, invasion and angiogenesis through suppression of the STAT3. SCLC cells were treated with curcumin (15 mmol/L) and the results showed that curcumin was effective in inhibiting STAT3 phosphorylation to downregulate of an array of STAT3 downstream targets ,which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion. Curcumin also suppressed the expression of proliferative proteins (Survivin, Bcl-XL and Cyclin B1), and invasive proteins (VEGF, MMP-2, MMP-7 and ICAM-1).Knockdown of STAT3 expression by siRNA was able to induce anti-invasive effects in vitro. In contrast,