有哪些信誉好的足球投注网站critical role of methylglyoxal and age in mycobacteria-induced macrophage apoptosis and activation甲基乙二醛和年龄的关键作用在mycobacteria-induced巨噬细胞凋亡和激活.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
critical role of methylglyoxal and age in mycobacteria-induced macrophage apoptosis and activation甲基乙二醛和年龄的关键作用在mycobacteria-induced巨噬细胞凋亡和激活
Critical Role of Methylglyoxal and AGE in Mycobacteria- Induced Macrophage Apoptosis and Activation 1 1 1 1 1 1 1 2 ¨ Helmy Rachman , Nayoung Kim , Timo Ulrichs , Sven Baumann , Lydia Pradl , Ali Nasser Eddine , Matthias Bild , Marion Rother , Ralf-Jurgen 3 1 4 4 5 1 Kuban , Jong Seok Lee , Robert Hurwitz , Volker Brinkmann , George A. Kosmiadi , Stefan H. E. Kaufmann * 1 Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany, 2 Max Planck Institute for Infection Biology, Department of ´ ¨ Molecular Biology, Berlin, Germany, 3 Laboratory of Functional Genomics, Charite, Universitatsmedizin Berlin, Berlin, Germany, 4 Max Planck Institute for Infection Biology, Core Facility, Berlin, Germany, 5 Central Tuberculosis Research Institute, Department of Immunology 2, Moscow, Russian Federation Apoptosis and activation of macrophages play an important role in the host response to mycobacterial infection involving TNF-a as a critical autocrine mediator. The underlying mechanisms are still ill-defined. Here, we demonstrate elevated levels of methylglyoxal (MG), a small and reactive molecule that is usually a physiological product of various metabolic pathways, and advanced glycation end products (AGE) during mycobacterial infection of macrophages, leading to apoptosis and activation of macrophages. Moreover, we demonstrate abundant AGE in pulmonary lesions of tuberculosis (TB) patients. Global gene expression profiling of MG-treated macrophages revealed a diverse spectrum of functions induced by MG, including apoptosis
您可能关注的文档
- conical tomography of a ribbon synapse structural evidence for vesicle fusion锥形断层带状突触结构的囊泡融合的证据.pdf
- conjugated molecules for the smart filtering of intense radiations智能过滤的共轭分子强烈的辐射.pdf
- conjugation of functionalized spions with transferrin for targeting and imaging brain glial tumors in rat model接合与转铁蛋白功能化spions瞄准和成像在老鼠大脑神经胶质肿瘤模型.pdf
- conjugation of proteins by installing bio-orthogonally reactive groups at their n-termini反应性基团结合的蛋白质通过安装bio-orthogonally n-termini.pdf
- conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease条件间充质pkd1中断导致骨量减少和多囊肾疾病.pdf
- conjugation to the cell-penetrating peptide tat potentiates the photodynamic effect of carboxytetramethylrhodamine结合到cell-penetrating肽答强化carboxytetramethylrhodamine的光动力效应.pdf
- conjunctival reconstruction with progenitor cell-derived autologous epidermal sheets in rhesus monkey结膜重建与祖细胞衍生自体表皮负债表恒河猴.pdf
- connecting mutations of the rna polymerase ii c-terminal domain to complex phenotypic changes using combined gene expression and network analyses连接突变的rna聚合酶ii c端域复杂表型变化使用基因表达和网络分析相结合.pdf
- connectivity practices and activity of greek political blogs希腊政治博客的连接方式和活动.pdf
- connectivity for healthcare and well-being management examples from six european projects连接的医疗保健和健康管理六个欧洲项目的例子.pdf
- critical loss of the balance between th17 and t regulatory cell populations in pathogenic siv infection关键th17之间失去平衡和调节t细胞数量在致病性siv感染.pdf
- critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor管理关键因素的差异antizyme-binding人类鸟氨酸脱羧酶和antizyme抑制剂之间的亲和力.pdf
- critical role of macrophages and their activation via myd88-nfκb signaling in lung innate immunity to mycoplasma pneumoniae关键作用的巨噬细胞及其在肺通过myd88-nfκb信号激活先天免疫肺炎支原体.pdf
- critical role of constitutive type i interferon response in bronchial epithelial cell to influenza infection关键作用的本构i型干扰素反应流感感染的支气管上皮细胞.pdf
- criticality of timing for anti-hiv therapy initiation临界抗艾滋病病毒治疗开始的时间.pdf
- cross modal perception of body size in domestic dogs (canis familiaris)交叉驯养狗的体型的看法(canis后裔).pdf
- critical role of the rb family in myoblast survival and fusionrb家族的重要作用在成肌细胞生存和融合.pdf
- critical role of neuropeptides bw receptor 1 signaling in social behavior and fear memory关键作用的神经肽bw受体1信号在社交行为和恐惧记忆.pdf
- critical role of klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneasklf5的至关重要的作用在调节基因表达在post-eyelid鼠标眼角膜的开始成熟.pdf
- cross tissue trait-pathway network reveals the importance of oxidative stress and inflammation pathways in obesity-induced diabetes in mouse跨组织trait-pathway网络揭示氧化应激和炎症通路的重要性obesity-induced糖尿病老鼠.pdf
文档评论（0）