critical loss of the balance between th17 and t regulatory cell populations in pathogenic siv infection关键th17之间失去平衡和调节t细胞数量在致病性siv感染.pdfVIP

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection 1 2. 1,3. 4. 2 1 David Favre , Sharon Lederer , Bittoo Kanwar , Zhong-Min Ma , Sean Proll , Zeljka Kasakow , Jeff 1 1 5 2,6 2 7 Mold , Louise Swainson , Jason D. Barbour , Carole R. Baskin , Robert Palermo , Ivona Pandrea , 4 2,6 1 Christopher J. Miller , Michael G. Katze , Joseph M. McCune * 1 Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America, 2 Department of Microbiology, University of Washington, Seattle, Washington, United States of America, 3 Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, California, United States of America, 4 Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, California, United States of America, 5 Department of Medicine, HIV/AIDS Division, University of California, San Francisco, California, United States of America, 6 Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America, 7 Tulane National Primate Research Center, Covington, Louisiana, United States of America Abstract Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species